2-methylacyl-CoA dehydrogenase

2-methylacyl-CoA dehydrogenase
Identifiers
EC number 1.3.99.12
CAS number 85130-32-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 2-methylacyl-CoA dehydrogenase (EC 1.3.99.12) is an enzyme that catalyzes the chemical reaction

2-methylbutanoyl-CoA + acceptor 2-methylbut-2-enoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and acceptor, whereas its two products are 2-methylbut-2-enoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include branched-chain acyl-CoA dehydrogenase, 2-methyl branched chain acyl-CoA dehydrogenase, and 2-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation.

References

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