2-oxoglutarate (2OG)-dependent dioxygenases

2-oxoglutarate (2OG)-dependent dioxygenases are enzymes that can induce the hydroxylation of distinct proteins and the demethylation of histones and DNA. 2-Oxoglutarate and oxygen are their obligatory substrates, along with Fe2+ as their cofactor.

These are sensors of energy metabolism.[1]

References

  1. ↑ "2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation... - PubMed - NCBI". Ncbi.nlm.nih.gov. Retrieved July 24, 2015.


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