6-Hydroxypseudooxynicotine dehydrogenase

6-hydroxypseudooxynicotine dehydrogenase (EC 1.5.99.14) is an enzyme with systematic name 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H₂O

\rightleftharpoons

1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor

This enzyime contains a cytidylyl molybdenum cofactor.

References

↑ Freudenberg, W.; Konig, K.; Andreesen, J. R. (1988). "Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase". FEMS Microbiology Letters. 52: 13–18. doi:10.1111/j.1574-6968.1988.tb02564.x.
↑ Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R. (1994). "Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans". Mol. Microbiol. 13 (5): 929–936. doi:10.1111/j.1365-2958.1994.tb00484.x. PMID 7815950.
↑ Sachelaru, P.; Schiltz, E.; Brandsch, R. (2006). "A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans". Appl. Environ. Microbiol. 72 (7): 5126–5131. doi:10.1128/AEM.00437-06. PMC 1489357. PMID 16820521.

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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