7-Chloro-L-tryptophan oxidase

7-Chloro-L-tryptophan oxidase (EC 1.4.3.23, RebO) is an enzyme with systematic name 7-chloro-L-tryptophan:oxygen oxidoreductase.^[1]^[2] This enzyme catalyses the following chemical reaction

7-chloro-L-tryptophan + O₂

\rightleftharpoons

2-imino-3-(7-chloroindol-3-yl)propanoate + H₂O₂

This enzyme contains a noncovalently bound FAD.

References

↑ Nishizawa, T.; Aldrich, C.C.; Sherman, D.H. (2005). "Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243". J. Bacteriol. 187 (6): 2084–2092. doi:10.1128/JB.187.6.2084-2092.2005. PMC 1064027. PMID 15743957.
↑ Howard-Jones, A.R.; Walsh, C.T. (2005). "Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD". Biochemistry. 44 (48): 15652–15663. doi:10.1021/bi051706e. PMID 16313168.

CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases

1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)

1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))

1.4.4: disulfide acceptor	Glycine cleavage system

1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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