CD2BP2

CD2BP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1GYF, 1L2Z, 1SYX, 4BWS

Identifiers

CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K, CD2 (cytoplasmic tail) binding protein 2, CD2 cytoplasmic tail binding protein 2

External IDs

MGI: 1917483 HomoloGene: 4455 GeneCards: CD2BP2

Gene ontology
Molecular function	• ribonucleoprotein complex binding • protein binding
Cellular component	• cytoplasm • U5 snRNP • nuclear speck • U4/U6 x U5 tri-snRNP complex • nucleus • nucleoplasm
Biological process	• negative regulation of phosphatase activity • mRNA splicing, via spliceosome • mRNA processing • spliceosomal tri-snRNP complex assembly • RNA splicing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


10421


70233


ENSG00000169217


ENSMUSG00000042502


O95400


Q9CWK3

RefSeq (mRNA)


NM_006110 NM_001243646


NM_001285905 NM_001285906 NM_001285907 NM_027353

RefSeq (protein)


NP_001230575.1 NP_006101.1 NP_001230575.1 NP_006101.1


NP_001272834.1 NP_001272835.1 NP_001272836.1 NP_081629.1

Location (UCSC)

Chr 16: 30.35 – 30.36 Mb

Chr 7: 127.19 – 127.2 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.^[3]^[4]

Interactions

CD2BP2 has been shown to interact with CD2.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
↑ "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
Cohavy O, Zhou J, Ware CF, Targan SR (2005). "LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.". J. Immunol. 174 (2): 646–53. doi:10.4049/jimmunol.174.2.646. PMID 15634882.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kofler M, Heuer K, Zech T, Freund C (2004). "Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.". J. Biol. Chem. 279 (27): 28292–7. doi:10.1074/jbc.M402008200. PMID 15105431.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Freund C, Kühne R, Yang H, et al. (2003). "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.". EMBO J. 21 (22): 5985–95. doi:10.1093/emboj/cdf602. PMC 137194. PMID 12426371.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Freund C, Dötsch V, Nishizawa K, et al. (1999). "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.". Nat. Struct. Biol. 6 (7): 656–60. doi:10.1038/10712. PMID 10404223.

PDB gallery

1gyf: GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN

1l2z: CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide

1syx: The crystal structure of a binary U5 snRNP complex

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