Centrin 1
Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[3][4] It belongs to the centrin family of proteins.
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[4]
References
Further reading
- Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247
. PMID 16760425.
- Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.". Mol. Cell. 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. PMID 16246726.
- Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
- Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro.". J. Cell. Sci. 113. ( Pt 8): 1355–64. PMID 10725219.
PDB gallery |
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| 1m39: Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form |
| 2a4j: Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein |
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