CHFR

CHFR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1LGP, 1LGQ, 2XOC, 2XOY, 2XOZ, 2XP0

Identifiers

CHFR, RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

External IDs

MGI: 2444898 HomoloGene: 10078 GeneCards: CHFR

Gene ontology
Molecular function	• nucleotide binding • zinc ion binding • ligase activity • protein binding • ubiquitin protein ligase activity • metal ion binding • ubiquitin-protein transferase activity
Cellular component	• PML body • nucleus
Biological process	• mitotic cell cycle checkpoint • cell division • mitotic cell cycle • cell cycle • protein polyubiquitination • modification-dependent protein catabolic process • mitotic nuclear division • positive regulation of protein ubiquitination • protein destabilization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • protein ubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


55743


231600


ENSG00000072609


ENSMUSG00000014668


Q96EP1


Q810L3

RefSeq (mRNA)


NM_018223 NM_001161344 NM_001161345 NM_001161346 NM_001161347


NM_001289577 NM_001289578 NM_001289579 NM_001289580 NM_172717

RefSeq (protein)


NP_001154816.1 NP_001154817.1 NP_001154818.1 NP_001154819.1 NP_060693.2


NP_001276506.1 NP_001276507.1 NP_001276508.1 NP_001276509.1 NP_766305.2

Location (UCSC)

Chr 12: 132.82 – 132.96 Mb

Chr 5: 110.14 – 110.17 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Scolnick DM, Halazonetis TD (Aug 2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature. 406 (6794): 430–5. doi:10.1038/35019108. PMID 10935642.
↑ Kang D, Chen J, Wong J, Fang G (Jan 2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J Cell Biol. 156 (2): 249–59. doi:10.1083/jcb.200108016. PMC 2199220. PMID 11807090.
↑ "Entrez Gene: CHFR checkpoint with forkhead and ring finger domains".

Further reading

Chaturvedi P, Sudakin V, Bobiak ML, et al. (2002). "Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity". Cancer Res. 62 (6): 1797–801. PMID 11912157.
Mizuno K, Osada H, Konishi H, et al. (2002). "Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers". Oncogene. 21 (15): 2328–33. doi:10.1038/sj.onc.1205402. PMID 11948416.
Stavridi ES, Huyen Y, Loreto IR, et al. (2002). "Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate". Structure. 10 (7): 891–9. doi:10.1016/S0969-2126(02)00776-1. PMID 12121644.
Shibata Y, Haruki N, Kuwabara Y, et al. (2002). "Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer". Carcinogenesis. 23 (10): 1695–9. doi:10.1093/carcin/23.10.1695. PMID 12376479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Corn PG, Summers MK, Fogt F, et al. (2003). "Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer". Carcinogenesis. 24 (1): 47–51. doi:10.1093/carcin/24.1.47. PMID 12538348.
Toyota M, Sasaki Y, Satoh A, et al. (2003). "Epigenetic inactivation of CHFR in human tumors". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7818–23. doi:10.1073/pnas.1337066100. PMC 164671. PMID 12810945.
Bothos J, Summers MK, Venere M, et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains". Oncogene. 22 (46): 7101–7. doi:10.1038/sj.onc.1206831. PMID 14562038.
Mariatos G, Bothos J, Zacharatos P, et al. (2004). "Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer". Cancer Res. 63 (21): 7185–9. PMID 14612512.
Shtivelman E (2004). "Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR". Mol. Cancer Res. 1 (13): 959–69. PMID 14638868.
Bertholon J, Wang Q, Falette N, et al. (2004). "Chfr inactivation is not associated to chromosomal instability in colon cancers". Oncogene. 22 (55): 8956–60. doi:10.1038/sj.onc.1207078. PMID 14654793.
Erson AE, Petty EM (2004). "CHFR-associated early G2/M checkpoint defects in breast cancer cells". Mol. Carcinog. 39 (1): 26–33. doi:10.1002/mc.10161. PMID 14694445.
Satoh A, Toyota M, Itoh F, et al. (2004). "Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer". Cancer Res. 63 (24): 8606–13. PMID 14695171.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kang HC, Kim IJ, Park JH, et al. (2005). "Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncol. Rep. 12 (1): 129–33. doi:10.3892/or.12.1.129. PMID 15201973.
Matsusaka T, Pines J (2004). "Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells". J. Cell Biol. 166 (4): 507–16. doi:10.1083/jcb.200401139. PMC 2172205. PMID 15302856.
Daniels MJ, Marson A, Venkitaraman AR (2004). "PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein". Nat. Struct. Mol. Biol. 11 (11): 1114–21. doi:10.1038/nsmb837. PMID 15467728.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1lgp: Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate

1lgq: Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein

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