Carbazole 1,9a-dioxygenase
| Carbazole 1,9a-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.12.22 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carbazole 1,9a-dioxygenase (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- 9H-carbazole + NAD(P)H + H+ + O2 2'-aminobiphenyl-2,3-diol + NAD(P)+
Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation.
References
- ↑ Nam, J.W.; Nojiri, H.; Noguchi, H.; Uchimura, H.; Yoshida, T.; Habe, H.; Yamane, H.; Omori, T. (2002). "Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Appl. Environ. Microbiol. 68 (12): 5882–5890. doi:10.1128/aem.68.12.5882-5890.2002. PMC 134387
. PMID 12450807. - ↑ Gai, Z.; Wang, X.; Liu, X.; Tai, C.; Tang, H.; He, X.; Wu, G.; Deng, Z.; Xu, P. (2010). "The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5". PLoS ONE. 5 (4): #e10018–e10018. doi:10.1371/journal.pone.0010018. PMC 2848856. PMID 20368802.
External links
- Carbazole 1,9a-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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