Corwin Hansch
| Corwin Hansch | |
|---|---|
| Born |
Corwin Herman Hansch October 6, 1918 Kenmare, North Dakota |
| Died |
May 8, 2011 (aged 92) Claremont, California |
| Nationality | American |
| Fields | Organic Chemistry |
| Institutions |
Pomona College Manhattan Project |
| Alma mater |
University of Illinois New York University |
| Notable awards | Tolman Award (1975) |
| Spouse | Gloria J. Hansch (nee Tomasulo) (m.1945?–2011) (his death) (1 child) |
Corwin Herman Hansch (October 6, 1918 – May 8, 2011)[1] was a Professor of Chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'[2]
Early life and childhood
He was born on October 6, 1918 in Kenmare, North Dakota.
Education
He earned a B.S. from the University of Illinois in 1940 and a Ph.D. from New York University in 1944.
Career
Hansch worked on the Manhattan Project at the University of Chicago and as a group leader at DuPont Nemours in Richland, Washington. In February 1946 he received an academic position at Pomona College.[3]
Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.
Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.
He is also noted for the Hansch equation, which is used in
- Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
- Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
- Hansch-Fujita constant - The Hansch-Fujita constant describes the contribution of a substituent to the lipophilicity of a compound.
Research Interests: Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).
- Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)
Death
He died of pneumonia on May 8, 2011 in Claremont, California at 92.[1]
Notes
His research group at Pomona College worked on QSAR studies and in building and expanding the database of chemical and physical data as C-QSAR and Bioloom. His postgraduate associates were Rajni Garg, Cynthia D Selassie, Suresh Babu Mekapati, and Alka Kurup.
The Journal of Computer-Aided Molecular Design carried four obituaries (as found in a Pubmed personal subject [ps] search).[4][5][6][7]
Bibliography
A preliminary search in WorldCat and in PubMed, two among many relevant bibliographic and citation indexes, shows the following:
- Books: WorldCat shows "53 works in 204 publications in 4 languages and 2,004 library holdings" for Hansch as "author, editor, other".[8] The top item in the list is "Exploring QSAR" by Corwin Hansch, Albert Leo and David Hoekman, an ACS professional reference book in 28 editions published between 1995 and 2014.
- Journal articles: 281 Pubmed records[9]
- Reviews: authored 33 reviews as indexed in Pubmed[10]
- Title word search: 56 Pubmed records[11]
The Pomona College Archives holds reprints of Hansch’s articles published between 1962 and 2009 in addition to other materials.[2]
References
- 1 2 Maugh, Thomas H. [II] (May 31, 2011). "Corwin Hansch dies at 92; scientist whose advances led to new drugs and chemicals". Los Angeles Times. Retrieved 5 August 2016.
- 1 2 Weber, Jamie (2013). "Guide to the Corwin Hansch Collection" (PDF). Pomona College Archives. Claremont, CA 91711. p. 3. Retrieved 5 August 2016.
- ↑ "1975 Tolman Award Medalist, Dr. Corwin Hansch, Carnegie Professor of Chemistry, Pomona College". Southern California Section of the American Chemical Society.
- ↑ Martin, Yvonne C (Jun 29, 2011). "Remembrances of Corwin Hansch". J Comput Aided Mol Des. 25 (6): 519–523. doi:10.1007/s10822-011-9452-y. PMID 21713458.
- ↑ Martin, Yvonne C; Stouch, Terry (June 28, 2011). "In tribute to Corwin Hansch, father of QSAR". J Comput Aided Mol Des. 25 (6): 491. doi:10.1007/s10822-011-9449-6. PMID 21710390.
- ↑ Fujita, Toshio (June 22, 2011). "In memoriam professor Corwin Hansch: birth pangs of QSAR before 1961". J Comput Aided Mol Des. 25 (6): 509–517. doi:10.1007/s10822-011-9450-0. PMID 21695492.
- ↑ Selassie, Cynthia Rachel (June 21, 2011). "Obituary: Corwin H. Hansch". J Comput Aided Mol Des. 25 (6): 493–494. doi:10.1007/s10822-011-9445-x. PMID 21691812.
- ↑ "[WorldCat search - books authored, edited, contributed]". WorldCat. Retrieved August 5, 2016.
- ↑ "281 articles, author search". Pubmed. Retrieved 5 August 2016.
- ↑ "33 authored reviews.". Pubmed. Retrieved 5 August 2016.
- ↑ "title word Pubmed records". PubMed. Retrieved 5 August 2016.
See also
External links
- Example for Hansch equation and Hansch-Fujita constant
- Corwin Hansch, The QSAR and Modelling Society News, October 1998
- Corwin Hansch Collection, Pomona College Archives. Pomona College. Claremont, CA 91711, Guide to the Corwin Hansch Collection
- Former homepage - url, Pomona College
- Corwin Hansch Award at the Hansch-Fujita Foundation, 2000-