Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Identifiers
EC number 1.1.1.333
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (EC 1.1.1.333, decaprenylphospho-beta-D-ribofuranose 2'-epimerase, Rv3791, DprE2) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+

The reaction is catalysed in the reverse direction.

References

  1. Trefzer, C.; Škovierová, H.; Buroni, S.; Bobovská, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.R.; Makarov, V.; Cole, S.T.; Riccardi, G.; Mikušová, K.; Johnsson, K. (2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2-oxidase DprE1". J. Am. Chem. Soc. 134 (2): 912–915. doi:10.1021/ja211042r. PMID 22188377.

External links

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