Derlin-3

DERL3

Identifiers

DERL3, C22orf14, IZP6, LLN2, derlin-3, derlin 3

External IDs

MGI: 1917627 HomoloGene: 41566 GeneCards: DERL3

Gene ontology
Molecular function	• protein binding
Cellular component	• integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • endoplasmic reticulum membrane • membrane
Biological process	• endoplasmic reticulum unfolded protein response • negative regulation of retrograde protein transport, ER to cytosol • protein N-linked glycosylation via asparagine • ER-associated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


91319


70377


n/a


ENSMUSG00000009092


Q96Q80


Q9D8K3

RefSeq (mRNA)


NM_001002862 NM_001135751 NM_198440


NM_024440

RefSeq (protein)


NP_001002862.1 NP_001129223.1 NP_940842.2


NP_077760.1

Location (UCSC)

Chr 22: 23.83 – 23.84 Mb

Chr 10: 75.89 – 75.9 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.^[3]^[4]

See also

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. doi:10.1038/nature02592. PMID 15215855.
↑ "Entrez Gene: DERL3 Der1-like domain family, member 3".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
Wang X, Bolotin D, Chu DH, et al. (2006). "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.". J. Cell Biol. 172 (3): 409–21. doi:10.1083/jcb.200510002. PMC 2063650. PMID 16449191.
Morrison JI, Lööf S, He P, Simon A (2006). "Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population.". J. Cell Biol. 172 (3): 433–40. doi:10.1083/jcb.200509011. PMC 2063652. PMID 16449193.

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