Dichloroarcyriaflavin A synthase
| Dichloroarcyriaflavin A synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.12.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Dichloroarcyriaflavin A synthase (EC 1.13.12.17) is an enzyme with systematic name dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+ dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation
References
- ↑ Makino, M.; Sugimoto, H.; Shiro, Y.; Asamizu, S.; Onaka, H.; Nagano, S. (2007). "Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton". Proc. Natl. Acad. Sci. USA. 104 (28): 11591–11596. doi:10.1073/pnas.0702946104. PMC 1913897
. PMID 17606921. - ↑ Howard-Jones, A.R.; Walsh, C.T. (2006). "Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid". J. Am. Chem. Soc. 128 (37): 12289–12298. doi:10.1021/ja063898m. PMID 16967980.
- ↑ Sanchez, C.; Zhu, L.; Brana, A.F.; Salas, A.P.; Rohr, J.; Mendez, C.; Salas, J.A. (2005). "Combinatorial biosynthesis of antitumor indolocarbazole compounds". Proc. Natl. Acad. Sci. USA. 102 (2): #461–466. doi:10.1073/pnas.0407809102. PMC 544307. PMID 15625109.
External links
- Dichloroarcyriaflavin A synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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