Festuclavine dehydrogenase

Festuclavine dehydrogenase
Identifiers
EC number 1.5.1.44
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Festuclavine dehydrogenase (EC 1.5.1.44, FgaFS, festuclavine synthase) is an enzyme with systematic name festuclavine:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

festuclavine + NAD+ 6,8-dimethyl-6,7-didehydroergoline + NADH + H+

The enzyme takes part in the biosynthesis of fumigaclavine C.

References

  1. Wallwey, C.; Matuschek, M.; Xie, X.L.; Li, S.M. (2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3". Org. Biomol. Chem. 8 (15): 3500–3508. doi:10.1039/c003823g. PMID 20526482.
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