GEM (gene)
GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.[3][4][5]
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. doi:10.1126/science.7912851. PMID 7912851.
- ↑ Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248
. PMID 11956230. - 1 2 "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle".
Further reading
- Cohen L, Mohr R, Chen YY, et al. (1995). "Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12448–52. doi:10.1073/pnas.91.26.12448. PMC 45455. PMID 7809057.
- Santoro T, Maguire J, McBride OW, et al. (1997). "Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein.". Genomics. 30 (3): 558–64. doi:10.1006/geno.1995.1277. PMID 8825643.
- Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
- Béguin P, Nagashima K, Gonoi T, et al. (2001). "Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.". Nature. 411 (6838): 701–6. doi:10.1038/35079621. PMID 11395774.
- Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J (2003). "A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.". Biochem. J. 367 (Pt 1): 57–65. doi:10.1042/BJ20020829. PMC 1222866. PMID 12093360.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kelly K (2006). "The RGK family: a regulatory tail of small GTP-binding proteins.". Trends Cell Biol. 15 (12): 640–3. doi:10.1016/j.tcb.2005.10.002. PMID 16242932.
- Opatowsky Y, Sasson Y, Shaked I, et al. (2006). "Structure-function studies of the G-domain from human gem, a novel small G-protein.". FEBS Lett. 580 (25): 5959–64. doi:10.1016/j.febslet.2006.09.067. PMC 1934412. PMID 17052716.
- Splingard A, Ménétrey J, Perderiset M, et al. (2007). "Biochemical and structural characterization of the gem GTPase.". J. Biol. Chem. 282 (3): 1905–15. doi:10.1074/jbc.M604363200. PMID 17107948.
PDB gallery |
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| 2cjw: CRYSTAL STRUCTURE OF THE SMALL GTPASE GEM (GEMDNDCAM) IN COMPLEX TO MG.GDP |
| 2g3y: Crystal structure of the human small GTPase GEM |
| 2ht6: Crystal structure of Human Gem G-domain bound to GDP |
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