Glycine oxidase

Glycine oxidase

Glycine oxidase tetramer, Geobacillus kaustophilus
Identifiers
EC number 1.4.3.19
CAS number 39307-16-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glycine oxidase (EC 1.4.3.19) is an enzyme with systematic name glycine:oxygen oxidoreductase (deaminating).[1][2] This enzyme catalyses the following chemical reaction

glycine + H2O + O2 glyoxylate + NH3 + H2O2 (overall reaction)
(1a) glycine + O2 2-iminoacetate + H2O2
(1b) 2-iminoacetate + H2O glyoxylate + NH3

This flavoenzyme containing non-covalently bound FAD.

References

  1. Job, V.; Marcone, G.L.; Pilone, M.S.; Pollegioni, L. (2002). "Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein". J. Biol. Chem. 277 (9): 6985–6993. doi:10.1074/jbc.M111095200. PMID 11744710.
  2. Nishiya, Y.; Imanaka, T. (1998). "Purification and characterization of a novel glycine oxidase from Bacillus subtilis". FEBS Lett. 438 (3): 263–266. doi:10.1016/s0014-5793(98)01313-1. PMID 9827558.
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