DEFA6

DEFA6
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases DEFA6, DEF6, HD-6, defensin alpha 6
External IDs HomoloGene: 130499 GeneCards: DEFA6
Orthologs
Species Human Mouse
Entrez

1671

n/a

Ensembl

ENSG00000164822

n/a

UniProt

Q01524

n/a

RefSeq (mRNA)

NM_001926

n/a

RefSeq (protein)

NP_001917.1

n/a

Location (UCSC) Chr 8: 6.92 – 6.93 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.[2][3] DEFA6 is expressed in the Paneth cells of the ileum.[4]

Function

The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 has poor antibacterial potency.[5] However, HD6 affords protection against invasion by enteric bacterial pathogens by self-assembly to form fibrils and nanonets that surround and entangle bacteria.[6]

Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.[2]

References

  1. ↑ "Human PubMed Reference:".
  2. 1 2 "Entrez Gene: DEFA6 defensin, alpha 6, Paneth cell-specific (Homo sapiens)".
  3. ↑ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. doi:10.1016/0014-5793(93)81160-2. PMID 8417977.
  4. ↑ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett. 396 (2–3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011.
  5. ↑ Ericksen B, Wu Z, Lu W, Lehrer RI (2005). "Antibacterial Activity and Specificity of the Six Human α-Defensins". Antimicrob Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877Freely accessible. PMID 15616305.
  6. ↑ Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL (2012). "Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets". Science. 337 (6093): 477–81. doi:10.1126/science.1218831. PMID 22722251.

Further reading


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