HPV-positive oropharyngeal cancer

HPV-positive oropharyngeal cancer
HPV positive HNSCC (in situ hybridization)
Classification and external resources
Specialty oncology
ICD-10 C09.0-C10.9
C01,C02.4,C14.2

Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) also known as HPV16+ oropharyngeal cancer or HPV+ OPC is a recognized subtype of oropharyngeal squamous cell carcinomas (OSCC),[1][2][3] associated with the HPV type 16 virus.

Causes

HPV oral infection precedes the development of HPV+ OPC.[4][5] Slight injuries in the mucous membrane serve as an entry gate for HPV, which thus works into the basal layer of the epithelium.[6][7] People testing positive for HPV16 oral infection have a 14 times increased risk of developing HPV+ OPC.[6]

Immunosuppression seems to be an increased risk factor for HPV+ OPC.[5] Individuals with TGF-β1 genetic variations, specially T869C, are more likely to have HPV16+ OPC.[8] TGF-β1 plays an important role in controlling the immune system.

A 1993 study has found that patients with human papillomavirus (HPV)-associated anogenital cancers had a 4.3-fold increased risk of tonsillar squamous-cell carcinoma.[9]

Although evidence suggests that HPV16 is the main cause of OPC between non-smokers and non-drinkers, the degree to which tobacco and/or alcohol use may contribute to increase the risk of HPV+ OPC is unclear.[5]

Concomitant human herpesvirus-8 infection can potentiate the effects of HPV-16.[10]

Mechanism

A prospective study has found that increased HPV+ OPC risk was observed more than 15 years after HPV exposure,[4] pointing to a slow development of the disease, like in cervical cancer.

HPV associated cancers are caused by the expression of HPV's E6 and E7 proteins that bind to and inactivate tumor suppressor proteins p53 and retinoblastoma protein (pRB), respectively, leading to malignant transformation of HPV infected cells.[4][11]

The biology of HPV+ OPC is distinct of HPV- OPC with P53 degradation (inactivated by E6 instead of by genetic mutation), pRB pathway inactivation (by E7 instead of Cyclin D1 amplification), and P16 upregulation (over-expression of p16 instead of inactivation due to reduced negative feedback from pRB).[12][13]

The tonsils epithelia (palatine and lingual) share similar nonkeratinization characteristics with the cervix, where HPV infection play the major role in cases of cervical cancer.[6][14]

Diagnosis

HPV+ OPC is usually diagnosed at a more advanced stage than HPV- OPC.[4]

Genetic signatures of HPV+ and HPV- OPC are different.[15][16][17][18][19]

HPV OPC is associated with expression level of the E6/E7 mRNAs and of p16.[20] Nonkeratinizing squamous cell carcinoma strongly predicts HPV-association.[21][22]

HPV OPC is not merely characterized by the presence of HPV-16. Only the expression of viral oncogenes within the tumor cells plus the serum presence of E6 or E7 antibodies is unambiguously conclusive.[6]

There's not a standard HPV testing method in head and neck cancers,[23] both in situ hybridization and PCR are commonly used.[12][24] A 2010 study has concluded that both have comparable performance for HPV detection, however it is important to use appropriate sensitivity controls.[25]

Prevention

Risk factors are high number of sexual partners,[26][27][28] (25% increase >= 6 partners)[29] history of oral-genital sex,[27][28] (125% >= 4 partners)[29] history of anal–oral sex,[27] female partner had a history of either an abnormal Pap smear or a cervical dysplasia,[27][30] chronic periodontitis,[31][32] and, among men, decreasing age at first intercourse[26] and history of genital warts.[26]

A 2010 study concluded that current tobacco users with advanced HPV+ OSCC are at higher risk of disease recurrence compared with never-tobacco users.[33]

HPV vaccines have a theoretical potential to prevent oral HPV infection.[4]

A 2010 review study has found that HPV16 oral infection was rare (1.3%) among the 3,977 healthy subjects analyzed.[34]

Treatment

Currently HPV+ OPC are treated similarly to stage-matched and site-matched unrelated OPC. However less intensive use of radiotherapy or chemotherapy, as well as specific therapy, is under research.[3][35]

It is hypothesized that HPV+ OPC patients benefit better from radiotherapy and concurrent cetuximab treatment than HPV- OPC patients receiving the same treatment.[36]

Prognosis

Tumor HPV status is strongly associated with positive therapeutic response and survival compared with HPV-negative OPC.[37][38][39] A possible explanation is "the lower probability of occurrence of 11q13 gene amplification, which is considered to be a factor underlying faster and more frequent recurrence of the disease"[6] Presence of TP53 mutations, a marker for HPV- OPC, is associated with worse prognosis.[4]

High grade of p16 staining is thought to be better than HPV PCR analysis in predicting radiotherapy response.[24]

Epidemiology

HPV+ OPC patients tend to be younger than HPV- patients.[40] Currently in the US there is a growing incidence of HPV associated oropharyngeal cancers,[41][42][43][44] perhaps as a result of changing sexual behaviors, decreased popularity of tonsillectomies, improved radiologic and pathologic evaluation, and changes in classification.[45][46][47] Tonsil and oropharyngeal cancers increased in male predominance between 1975 and 2004, despite reductions in smoking.[48] The decline in smoking may be linked to the decreasing proportion of HPV negative cancers, while changes in sexual activity may be reflected in increasing proportion of HPV positive cancers.[49] Recently, in the US, HPV associated OPC represent about 60% of OPC cases[37][50][51] compared with 40% in the previous decade.[51] By 2007, in the US, incidence of general OPC, including non-HPV associated, is 3.2 cases per 100,000 males/year and 1.9 per 100,000 all-sexes/year.[52]

The higher increase incidence of HPV associated OPC is also seen in other countries, like Sweden, with a 2007 incidence of over 80% for cancer in the tonsils,[53][54] Finland[55] and Czech Republic.[56] Partners of patients with HPV positive oropharyngeal cancer do not seem to have elevated oral HPV infection compared with the general population.[57] In Australia incidence of HPV associated OPC is 1.56 cases per 100,000 males/year.[58]

History

In 1983, it was first suggested[5] that HPV might be the agent involved in the development of at least certain special types of oral cancers.[59] In 2007 the World Health Organization stated HPV was a cause for oral cancers.[4][60]

References

  1. ↑ Westra, W. H. (2009). "The Changing Face of Head and Neck Cancer in the 21st Century: the Impact of HPV on the Epidemiology and Pathology of Oral Cancer". Head and Neck Pathology. 3 (1): 78–81. doi:10.1007/s12105-009-0100-y. PMC 2807531Freely accessible. PMID 20596995.
  2. ↑ Gillison, M. L.; Koch, W. M.; Capone, R. B.; Spafford, M.; Westra, W. H.; Wu, L.; Zahurak, M. L.; Daniel, R. W.; Viglione, M.; Symer, D. E.; Shah, K. V.; Sidransky, D. (May 2000). "Evidence for a causal association between human papillomavirus and a subset of head and neck cancers" (Free full text). Journal of the National Cancer Institute. 92 (9): 709–720. doi:10.1093/jnci/92.9.709. ISSN 0027-8874. PMID 10793107.
  3. 1 2 Psyrri, A.; Gouveris, P.; Vermorken, J. B. (2009). "Human papillomavirus-related head and neck tumors: clinical and research implication". Current Opinion in Oncology. 21 (3): 201–205. doi:10.1097/CCO.0b013e328329ab64. PMID 19370803.
  4. 1 2 3 4 5 6 7 Chaturvedi, Anil; Maura L. Gillison (March 4, 2010). "Human Papillomavirus and Head and Neck Cancer". In Andrew F. Olshan. Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer (1st ed.). New York: Springer. ISBN 978-1-4419-1471-2.
  5. 1 2 3 4 Mannarini, L.; Kratochvil, V.; Calabrese, L.; Gomes Silva, L.; Morbini, P.; Betka, J.; Benazzo, M. (2009). "Human Papilloma Virus (HPV) in head and neck region: review of literature". Acta Otorhinolaryngologica Italica. 29 (3): 119–126. PMC 2815356Freely accessible. PMID 20140157.
  6. 1 2 3 4 5 Michl, P; Pazdera, J; Prochazka, M; Pink, R; Stosova, T (2010). "Human papillomavirus in the etiology of head and neck carcinomas" (PDF). Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 154 (1): 9–12. doi:10.5507/bp.2010.004. PMID 20445705.
  7. ↑ Vidal, L.; Gillison, M. (2008). "Human papillomavirus in HNSCC: recognition of a distinct disease type". Hematology/oncology clinics of North America. 22 (6): 1125–1142, vii. doi:10.1016/j.hoc.2008.08.006. PMID 19010263.
  8. ↑ Guan, X.; Sturgis, E.; Lei, D.; Liu, Z.; Dahlstrom, K.; Wei, Q.; Li, G. (2010). "Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer". Clinical Cancer Research. 16 (5): 1416–1422. doi:10.1158/1078-0432.CCR-09-2877. PMC 2831118Freely accessible. PMID 20179236.
  9. ↑ Frisch, M.; Biggar, R. (1999). "Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas". The Lancet. 354 (9188): 1442–3. doi:10.1016/S0140-6736(99)92824-6. PMID 10543674.
  10. ↑ Underbrink, M.; Hoskins, S.; Pou, A.; Albrecht, T. (2008). "Viral interaction: a possible contributing factor in head and neck cancer progression". Acta Oto-Laryngologica. 128 (12): 1361–1369. doi:10.1080/00016480801965001. PMID 18607925.
  11. ↑ Smeets, S.; Van Der Plas, M.; Schaaij-Visser, T.; Van Veen, E.; Van Meerloo, J.; Braakhuis, B.; Steenbergen, R.; Brakenhoff, R. (2010). "Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways". International Journal of Cancer. Journal International Du Cancer. 128 (7): n/a. doi:10.1002/ijc.25474. PMID 20499310.
  12. 1 2 Marur, S.; D'souza, G.; Westra, W. H.; Forastiere, A. A. (2010). "HPV-associated head and neck cancer: a virus-related cancer epidemic". The Lancet Oncology. 11 (8): 781–789. doi:10.1016/S1470-2045(10)70017-6. PMID 20451455.
  13. ↑ Hunt, Jennifer L. (25 February 2010). "Molecular Assessment of HPV in Patients with Head and Neck Tumors" (PDF). Retrieved 13 May 2010.
  14. ↑ Salem, A. (2010). "Dismissing links between HPV and aggressive tongue cancer in young patients". Annals of Oncology. 21 (1): 13–17. doi:10.1093/annonc/mdp380. PMID 19825879.
  15. ↑ Klussmann, J.; Mooren, J.; Lehnen, M.; Claessen, S.; Stenner, M.; Huebbers, C.; Weissenborn, S.; Wedemeyer, I.; Preuss, S.; Straetmans, J. M. J. A. A.; Manni, J. J.; Hopman, A. H. N.; Speel, E. -J. M. (Mar 2009). "Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications". Clinical Cancer Research. 15 (5): 1779–1786. doi:10.1158/1078-0432.CCR-08-1463. ISSN 1078-0432. PMID 19223504.
  16. ↑ Lohavanichbutr, P.; Houck, J.; Fan, W.; Yueh, B.; Mendez, E.; Futran, N.; Doody, D.; Upton, M.; Farwell, D.; Schwartz, S. M.; Zhao, L. P.; Chen, C. (Feb 2009). "Genome-wide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices". Archives of Otolaryngology—Head & Neck Surgery. 135 (2): 180–188. doi:10.1001/archoto.2008.540. ISSN 0886-4470. PMC 2761829Freely accessible. PMID 19221247.
  17. ↑ Schlecht, N.; Burk, R.; Adrien, L.; Dunne, A.; Kawachi, N.; Sarta, C.; Chen, Q.; Brandwein-Gensler, M.; Prystowsky, M.; Childs, G.; Smith, R. V.; Belbin, T. J. (Nov 2007). "Gene expression profiles in HPV-infected head and neck cancer". The Journal of pathology. 213 (3): 283–293. doi:10.1002/path.2227. ISSN 0022-3417. PMID 17893858.
  18. ↑ Weinberger, P.; Yu, Z.; Kountourakis, P.; Sasaki, C.; Haffty, B.; Kowalski, D.; Merkley, M.; Rimm, D.; Camp, R.; Psyrri, A. (Sep 2009). "Defining molecular phenotypes of human papillomavirus-associated oropharyngeal squamous cell carcinoma: Validation of three-class hypothesis". Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 141 (3): 382–389.e1. doi:10.1016/j.otohns.2009.04.014. ISSN 0194-5998. PMID 19716018.
  19. ↑ Martinez, I.; Wang, J.; Hobson, K.; Ferris, R.; Khan, S. (Jan 2007). "Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas". European journal of cancer (Oxford, England : 1990). 43 (2): 415–432. doi:10.1016/j.ejca.2006.09.001. ISSN 0959-8049. PMC 1847595Freely accessible. PMID 17079134.
  20. ↑ Jung, A.; Briolat, J.; Millon, R.; De Reyniès, A.; Rickman, D.; Thomas, E.; Abecassis, J.; Clavel, C.; Wasylyk, B. (2009). "Biological and clinical relevance of transcriptionnally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma". International Journal of Cancer. Journal International Du Cancer. 126 (8): 1882–1894. doi:10.1002/ijc.24911. PMID 19795456.
  21. ↑ Chernock, R. D.; El-mofty, S. K.; Thorstad, W. L.; Parvin, C. A.; Lewis, J. S. (2009). "HPV-Related Nonkeratinizing Squamous Cell Carcinoma of the Oropharynx: Utility of Microscopic Features in Predicting Patient Outcome". Head and Neck Pathology. 3 (3): 186–194. doi:10.1007/s12105-009-0126-1. PMC 2811624Freely accessible. PMID 20596971.
  22. ↑ Elmofty, S.; Patil, S. (2006). "Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: Characterization of a distinct phenotype". Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 101 (3): 339–345. doi:10.1016/j.tripleo.2005.08.001. PMID 16504868.
  23. ↑ Robinson, M.; Sloan, P.; Shaw, R. (2010). "Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing.". Oral oncology. 46 (7): 492–496. doi:10.1016/j.oraloncology.2010.02.013. PMID 20227331.
  24. 1 2 Munck-Wikland, Eva; Hammarstedt, Lalle; Dahlstrand, Hanna (2010). "Role of Human Papillomavirus in Tonsillar Cancer". In M. A. Hayat. Methods of Cancer Diagnosis, Therapy, and Prognosis. 7. Springer. pp. 271–283. ISBN 978-90-481-3185-3.
  25. ↑ Agoston, E. .; Robinson, S. .; Mehra, K. .; Birch, C. .; Semmel, D. .; Mirkovic, J. .; Haddad, R. .; Posner, M. .; Kindelberger, D. .; Krane, J. F.; Brodsky, J.; Crum, C. P. (2010). "Polymerase chain reaction detection of HPV in squamous carcinoma of the oropharynx". American journal of clinical pathology. 134 (1): 36–41. doi:10.1309/AJCP1AAWXE5JJCLZ. PMID 20551264.
  26. 1 2 3 Schwartz, S. M.; Daling, J. R.; Doody, D. R.; Wipf, G. C.; Carter, J. J.; Madeleine, M. M.; Mao, E. J.; Fitzgibbons, E. D.; Huang, S.; Beckmann, A. M.; McDougall, J. K.; Galloway, D. A. (1998). "Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection". Journal of the National Cancer Institute. 90 (21): 1626–1636. doi:10.1093/jnci/90.21.1626. PMID 9811312.
  27. 1 2 3 4 Smith, E.; Ritchie, J.; Summersgill, K.; Klussmann, J.; Lee, J.; Wang, D.; Haugen, T.; Turek, L. (Feb 2004). "Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers". International Journal of Cancer. Journal International Du Cancer. 108 (5): 766–772. doi:10.1002/ijc.11633. ISSN 0020-7136. PMID 14696105.
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  29. 1 2 Heck, J.; Berthiller, J.; Vaccarella, S.; Winn, D.; Smith, E.; Shan'Gina, O.; Schwartz, S.; Purdue, M.; Pilarska, A.; Eluf-Neto, J.; Menezes, A.; McClean, M. D.; Matos, E.; Koifman, S.; Kelsey, K. T.; Herrero, R.; Hayes, R. B.; Franceschi, S.; Wünsch-Filho, V.; Fernández, L.; Daudt, A. W.; Curado, M. P.; Chen, C.; Castellsagué, X.; Ferro, G.; Brennan, P.; Boffetta, P.; Hashibe, M. (2009). "Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium". International Journal of Epidemiology. 39 (1): 166–181. doi:10.1093/ije/dyp350. PMC 2817092Freely accessible. PMID 20022926.
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  32. ↑ Tezal, M.; Sullivan, M.; Hyland, A.; Marshall, J.; Stoler, D.; Reid, M.; Loree, T.; Rigual, N.; Merzianu, M.; Hauck, L.; Lillis, C.; Wactawski-Wende, J.; Scannapieco, F. A. (2009). "Chronic periodontitis and the incidence of head and neck squamous cell carcinoma". Cancer Epidemiology, Biomarkers & Prevention. 18 (9): 2406–2412. doi:10.1158/1055-9965.EPI-09-0334. PMID 19745222.
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  57. ↑ D'Souza G, Gross ND, Pai SI, et al. (2014). "Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners". J Clin Oncol. 32: 2408–2415. doi:10.1200/JCO.2014.55.1341.
  58. ↑ Hong, A. M.; Grulich, A. E.; Jones, D.; Lee, C. S.; Garland, S. M.; Dobbins, T. A.; Clark, J. R.; Harnett, G. B.; Milross, C. G.; O'Brien, C. J.; Rose, B. R. (2010). "Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets". Vaccine. 28 (19): 3269–3272. doi:10.1016/j.vaccine.2010.02.098. PMID 20226244.
  59. ↑ Syrjänen, K.; Syrjänen, S.; Lamberg, M.; Pyrhönen, S.; Nuutinen, J. (1983). "Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis". International journal of oral surgery. 12 (6): 418–424. doi:10.1016/S0300-9785(83)80033-7. PMID 6325356.
  60. ↑ International Agency for Research on Cancer (2007) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. vol 90: Human Papillomaviruses

Further reading

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