HS3ST1

HS3ST1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZRH

Identifiers

HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1

External IDs

MGI: 1201606 HomoloGene: 3751 GeneCards: HS3ST1

Gene ontology
Molecular function	• transferase activity • sulfotransferase activity • [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]
Cellular component	• Golgi lumen • integral component of membrane • Golgi apparatus
Biological process	• glycosaminoglycan biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


9957


15476


ENSG00000002587


ENSMUSG00000051022


O14792


O35310

RefSeq (mRNA)


NM_005114


NM_010474

RefSeq (protein)


NP_005105.1


NP_034604.1

Location (UCSC)

Chr 4: 11.39 – 11.43 Mb

Chr 5: 39.61 – 39.76 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.^[3]^[4]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
1 2 "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".

Further reading

Razi N, Lindahl U (1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.". J. Biol. Chem. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.
Liu J, Shworak NW, Fritze LM, et al. (1996). "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase.". J. Biol. Chem. 271 (43): 27072–82. doi:10.1074/jbc.271.43.27072. PMID 8900198.
Shworak NW, Liu J, Fritze LM, et al. (1997). "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase.". J. Biol. Chem. 272 (44): 28008–19. doi:10.1074/jbc.272.44.28008. PMID 9346953.
Liu J, Shworak NW, Sinaÿ P, et al. (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.". J. Biol. Chem. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
Hernaiz M, Liu J, Rosenberg RD, Linhardt RJ (2000). "Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III.". Biochem. Biophys. Res. Commun. 276 (1): 292–7. doi:10.1006/bbrc.2000.3453. PMID 11006120.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Edavettal SC, Carrick K, Shah RR, et al. (2004). "A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.". Biochemistry. 43 (16): 4680–8. doi:10.1021/bi0499112. PMID 15096036.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1vkj: Crystal structure of heparan sulfate 3-O-sulfotransferase isoform 1 in the presence of PAP

1zrh: Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP

This article is issued from Wikipedia - version of the 5/31/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.