HYAL2

HYAL2
Identifiers
Aliases	HYAL2, LUCA2, hyaluronoglucosaminidase 2
External IDs	MGI: 1196334 HomoloGene: 7776 GeneCards: HYAL2
Gene ontology Molecular function • RNA polymerase II transcription coactivator activity • hyaluronoglucuronidase activity • catalytic activity • virus receptor activity • hyalurononglucosaminidase activity • receptor tyrosine kinase binding • hydrolase activity, acting on glycosyl bonds • protein binding • hyaluronic acid binding • enzyme binding • receptor signaling protein tyrosine kinase inhibitor activity • hydrolase activity • transforming growth factor beta binding Cellular component • cytoplasm • cytosol • membrane • anchored component of plasma membrane • Golgi membrane • plasma membrane • endocytic vesicle • cytoplasmic, membrane-bounded vesicle • microvillus • cell surface • RNA polymerase II transcription factor complex • apical plasma membrane • endoplasmic reticulum • anchored component of external side of plasma membrane • perinuclear region of cytoplasm • membrane raft • anchored component of membrane • lysosome • cytoplasmic vesicle Biological process • cellular response to transforming growth factor beta stimulus • negative regulation of protein kinase B signaling • negative regulation of fibroblast migration • positive regulation of inflammatory response • hyaluronan catabolic process • positive regulation of interleukin-6 secretion • positive regulation of urine volume • kidney development • response to reactive oxygen species • response to antibiotic • cellular response to tumor necrosis factor • response to virus • skeletal system morphogenesis • cellular response to fibroblast growth factor stimulus • monocyte activation • multicellular organismal iron ion homeostasis • cartilage development • negative regulation of protein tyrosine kinase activity • fusion of virus membrane with host plasma membrane • cellular response to UV-B • glycosaminoglycan catabolic process • negative regulation of MAP kinase activity • negative regulation of cell growth • hematopoietic progenitor cell differentiation • multicellular organism aging • cellular response to interleukin-1 • positive regulation of interleukin-8 secretion • positive regulation of protein import into nucleus • positive regulation of extrinsic apoptotic signaling pathway • metabolic process • renal water absorption • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • transformation of host cell by virus • viral entry into host cell • carbohydrate metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8692	15587
Ensembl	ENSG00000068001	ENSMUSG00000010047
UniProt	Q12891	O35632
RefSeq (mRNA)	NM_003773 NM_033158	NM_010489
RefSeq (protein)	NP_003764.3 NP_149348.2	NP_034619.2
Location (UCSC)	Chr 3: 50.32 – 50.32 Mb	Chr 9: 107.57 – 107.57 Mb
PubMed search	[1]	[2]
Wikidata

Hyaluronidase-2 is an enzyme that in humans is encoded by the HYAL2 gene.^[3][4][5]

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.^[5]

References

Further reading