Interleukin 28 receptor, alpha subunit

IFNLR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OG4, 3OG6, 5IXI, 5IXD
Identifiers
Aliases	IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2, Interleukin 28 receptor, alpha subunit, interferon lambda receptor 1
External IDs	MGI: 2429859 HomoloGene: 52086 GeneCards: IFNLR1
Gene ontology Molecular function • cytokine receptor activity • protein binding Cellular component • integral component of membrane • interleukin-28 receptor complex • membrane • plasma membrane Biological process • response to type III interferon • mucosal immune response • defense response to virus • negative regulation of cell proliferation • regulation of defense response to virus by host • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	163702	242700
Ensembl	ENSG00000185436	ENSMUSG00000062157
UniProt	Q8IU57	Q8CGK5
RefSeq (mRNA)	NM_170743 NM_173064 NM_173065	NM_174851
RefSeq (protein)	NP_734464.1 NP_775087.1 NP_775088.1	NP_777276.3
Location (UCSC)	Chr 1: 24.15 – 24.19 Mb	Chr 4: 135.69 – 135.71 Mb
PubMed search	[1]	[2]
Wikidata

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[3]

References