Johan Paulsson

Johan Paulsson
Born Kristinehamn, Sweden
Residence U.S.A.
Citizenship Sweden
Fields Systems biology, Mathematical biology, Stochastic Process
Institutions Harvard
Alma mater Uppsala University (M.S.,Ph.D.)

Johan Paulsson is a Swedish mathematician and systems biologist at Harvard Medical School. He is a leading researcher in systems biology and stochastic processes, specializing in stochasticity in gene networks and plasmid reproduction.

Biography

Johan Paulsson was born in 1973, in Kristinehamn, a small city in the Swedish province of Värmland. He studied at Uppsala University, where he obtained a BSc in Mathematics in 1996, a Masters of Science in Molecular Biology in 1996, and a Ph.D. in Molecular Biology in 2000 on stochasticity in intracellular circuits, in particular in plasmid copy control, under the supervision of Profs. Mans Ehrenberg and Kurt Nordström. In 2000 he moved to Princeton University, where he was a Lewis-Thomas Fellow in Biophysics, where he did the research for his paper "Summing up the noise in genetic networks", which received wide attention because it gave a firm theoretical footing to the budding field of genetic noise. In 2003 he joined the Dept. of Applied Mathematics and Theoretical Physics at the University of Cambridge and was tenured the following year. In 2005 he moved to the recently created Department of Systems Biology at Harvard University, where he focused on the development of experimental techniques for counting plasmids in single cells and on theoretical results on control of fluctuations in gene expression.

He is married with two children.

Work

His lab focused on the development of experimental techniques for counting plasmids, to extend his previous work on the mathematical aspects of plasmid replication[1][2][3][4][5] as well as theoretical work on the stochastic processes on gene expression and copy number control[6][7][8][9][10] and work on muti-level selection[11] by using experimental evolution.

His most influential publication is the analysis of all previous noise data and interpretations in one unified framework,[12][13] which later guided many experimental approaches.[14][15][16]

His latest results are on the effects of partition in phenotypic variability,[17] the details of the stochastic processes that underlie gene expression noise and the limitations of the usual experimental approaches[18][19] and the fundamental limits of feedback as a noise control mechanism.[20]

References

  1. ↑ Paulsson, J; K. Nordström; and M.Ehrenberg (1998). "Requirements for rapid plasmid copy number adjustments". Plasmid. 39: 215. doi:10.1006/plas.1998.1338.
  2. ↑ Paulsson, J; M.Ehrenberg (1998). "Trade-off between segregational stability and metabolic burden". J. Mol. Biol. 279 (1): 73–88. doi:10.1006/jmbi.1998.1751. PMID 9636701.
  3. ↑ Paulsson, J; M.Ehrenberg (2000). "Molecular clocks reduce plasmid losses: the R1 case.". J. Mol. Biol. 279 (1): 179–92. doi:10.1006/jmbi.2000.3526. PMID 10704315.
  4. ↑ Paulsson, J; M.Ehrenberg (2000). "Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks". Phys. Rev. Lett. 23 (23): 5447–50. Bibcode:2000PhRvL..84.5447P. doi:10.1103/PhysRevLett.84.5447. PMID 10990965.
  5. ↑ Park, K.; E. Han; J. Paulsson; D. K. Chattoraj (2001). "Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number". EMBO J. 20 (24): 7223. doi:10.1093/emboj/20.24.7323. PMC 125786Freely accessible. PMID 11743008.
  6. ↑ Paulsson, J; O. G. Berg; M. Ehrenberg (2000). "Stochastic Focusing: Fluctuation enhanced sensitivity of intracellular regulation". Proc. Natl. Acad. Sci. U.S.A. 13 (13): 7148–53. Bibcode:2000PNAS...97.7148P. doi:10.1073/pnas.110057697. PMC 16514Freely accessible. PMID 10852944.
  7. ↑ Berg, O. G.; J. Paulsson; M. Ehrenberg (2000). "Fluctuations and quality of control in biological cells – Zero order ultrasensitivity reinvestigated". Biophys. J. 79 (3): 1228–36. Bibcode:2000BpJ....79.1228B. doi:10.1016/S0006-3495(00)76377-6. PMC 1301019Freely accessible. PMID 10968987.
  8. ↑ Berg, O. G.; J. Paulsson; M. Ehrenberg (2000). "Fluctuations in repressor control: Thermodynamic constraints on Stochastic Focusing". Biophys. J. 79 (6): 2944–53. Bibcode:2000BpJ....79.2944B. doi:10.1016/S0006-3495(00)76531-3. PMC 1301173Freely accessible. PMID 11106602.
  9. ↑ Paulsson, J; M.Ehrenberg (2001). "Noise in a minimal regulatory network: plasmid copy number control". Quart. Rev. of Biophys. 34 (1): 1–59. doi:10.1017/s0033583501003663. PMID 11388089.
  10. ↑ Elf, J.; J. Paulsson; O. G. Berg; M. Ehrenberg (2003). "Near-critical phenomena in intracellular metabolite pools". Biophys. J. 84 (1): 154–70. Bibcode:2003BpJ....84..154E. doi:10.1016/S0006-3495(03)74839-5. PMC 1302600Freely accessible. PMID 12524272.
  11. ↑ Paulsson, J (2002). "Noise in a minimal regulatory network: plasmid copy number control". Genetics. 161 (4): 1373–84. PMC 1462198Freely accessible. PMID 12238464.
  12. ↑ Paulsson, J (2004). "Summing up the noise in gene networks". Nature. 427 (6973): 415–8. Bibcode:2004Natur.427..415P. doi:10.1038/nature02257. PMID 14749823.
  13. ↑ Paulsson, J (2005). "Models of Stochastic Gene Expression.". Phys. Life Rev. 2: 157. Bibcode:2005PhLRv...2..157P. doi:10.1016/j.plrev.2005.03.003.
  14. ↑ Golding, I; Paulsson J; Zawilski SM; Cox EC. (2005). "Real-time kinetics of gene activity in individual bacteria.". Cell. 123 (6): 1025–36. doi:10.1016/j.cell.2005.09.031. PMID 16360033.
  15. ↑ Bar-Even, A; Paulsson J; Maheshri N; Carmi M; O'Shea E; Pilpel Y; Barkai N. (2006). "Noise in protein expression scales with natural protein abundance.". Nat. Genet. 38 (6): 636–43. doi:10.1038/ng1807. PMID 16715097.
  16. ↑ Rando, O J; J. Paulsson (2006). "Noisy silencing of chromatin.". Cell. 11 (2): 134–6. doi:10.1016/j.devcel.2006.07.012. PMID 16890152.
  17. ↑ Huh, D; J. Paulsson (2011). "Non-genetic heterogeneity from stochastic partitioning at cell division.". Nat. Genet. 43 (2): 95–100. doi:10.1038/ng.729. PMC 3208402Freely accessible. PMID 21186354.
  18. ↑ Pedraza, J M; J. Paulsson (2008). "Effects of molecular memory and bursting on fluctuations in gene expression". Science. 319: 339. Bibcode:2008Sci...319..339P. doi:10.1126/science.1144331.
  19. ↑ Hilfinger, A; J. Paulsson (2011). "Separating intrinsic from extrinsic fluctuations in dynamic biological systems". Proc. Natl. Acad. Sci. U.S.A. 108: 12167. doi:10.1073/pnas.1018832108.
  20. ↑ Lestas, I; G. Vinnicombe; J. Paulsson (2010). "Fundamental limits on the suppression of molecular fluctuations". Nature. 467 (7312): 163. Bibcode:2010Natur.467..174L. doi:10.1038/nature09333. PMC 2996232Freely accessible. PMID 20829788.

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