KIN (gene)

KIN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CKK, 2V1N

Identifiers

KIN, BTCD, KIN17, Rts2, Kin17 DNA and RNA binding protein

External IDs

MGI: 96676 HomoloGene: 8196 GeneCards: KIN

Gene ontology
Molecular function	• DNA binding • double-stranded DNA binding • metal ion binding • RNA binding
Cellular component	• cytoplasm • nuclear matrix • intracellular membrane-bounded organelle • nucleus
Biological process	• DNA replication • mRNA processing • DNA recombination • viral process • DNA repair • cellular response to DNA damage stimulus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


22944


16588


ENSG00000151657


ENSMUSG00000037262


O60870


Q8K339

RefSeq (mRNA)


NM_012311


NM_025280

RefSeq (protein)


NP_036443.1


NP_079556.1

Location (UCSC)

Chr 10: 7.75 – 7.79 Mb

Chr 2: 10.08 – 10.09 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.^[3]^[4]

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC 328864. PMID 1923796.
1 2 "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".

Further reading

Biard DS, Saintigny Y, Maratrat M, et al. (1997). "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin.". Arch. Dermatol. Res. 289 (8): 448–56. doi:10.1007/s004030050220. PMID 9266022.
Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells.". J. Cell. Sci. 112 (19): 3215–24. PMID 10504327.
Blattner C, Kannouche P, Litfin M, et al. (2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs.". Mol. Cell. Biol. 20 (10): 3616–25. doi:10.1128/MCB.20.10.3616-3625.2000. PMC 85654. PMID 10779351.
Kannouche P, Mauffrey P, Pinon-Lataillade G, et al. (2000). "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans.". Carcinogenesis. 21 (9): 1701–10. doi:10.1093/carcin/21.9.1701. PMID 10964102.
Biard DS, Miccoli L, Despras E, et al. (2002). "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells.". J. Biol. Chem. 277 (21): 19156–65. doi:10.1074/jbc.M200321200. PMID 11880372.
Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication.". Cancer Res. 62 (19): 5425–35. PMID 12359749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masson C, Menaa F, Pinon-Lataillade G, et al. (2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 616–21. doi:10.1073/pnas.0236176100. PMC 141045. PMID 12525703.
Despras E, Miccoli L, Créminon C, et al. (2003). "Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.". Radiat. Res. 159 (6): 748–58. doi:10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2. ISSN 0033-7587. PMID 12751957.
Biard DS, Miccoli L, Despras E, et al. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID 12754299.
Miccoli L, Biard DS, Frouin I, et al. (2003). "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner". Nucleic Acids Res. 31 (14): 4162–75. doi:10.1093/nar/gkg459. PMC 165974. PMID 12853634.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Miccoli L, Frouin I, Novac O, et al. (2005). "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins". Mol. Cell. Biol. 25 (9): 3814–30. doi:10.1128/MCB.25.9.3814-3830.2005. PMC 1084281. PMID 15831485.
le Maire A, Schiltz M, Braud S, et al. (2006). "Crystallization and halide phasing of the C-terminal domain of human KIN17". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 3): 245–8. doi:10.1107/S174430910600409X. PMC 2197188. PMID 16511313.
le Maire A, Schiltz M, Stura EA, et al. (2007). "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics". J. Mol. Biol. 364 (4): 764–76. doi:10.1016/j.jmb.2006.09.033. PMID 17045609.

PDB gallery

2ckk: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN KIN17 C-TERMINAL DOMAIN CONTAINING A KOW MOTIF KIN17.

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