MARCH6

MARCH6

Identifiers

MARCH6, DOA10, MARCH-VI, RNF176, TEB4, membrane associated ring-CH-type finger 6

External IDs

MGI: 2442773 HomoloGene: 4301 GeneCards: MARCH6

Gene ontology
Molecular function	• enzyme binding • ubiquitin-specific protease binding • zinc ion binding • ligase activity • ubiquitin conjugating enzyme binding • ubiquitin protein ligase activity involved in ERAD pathway • metal ion binding • ubiquitin-protein transferase activity
Cellular component	• integral component of membrane • integral component of endoplasmic reticulum membrane • ER ubiquitin ligase complex • membrane • endoplasmic reticulum • endoplasmic reticulum membrane
Biological process	• protein K48-linked ubiquitination • proteasomal protein catabolic process • ERAD pathway • protein ubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


10299


223455


ENSG00000145495


ENSMUSG00000039100


O60337


Q6ZQ89

RefSeq (mRNA)


NM_001270660 NM_001270661 NM_005885


NM_172606

RefSeq (protein)


NP_001257589.1 NP_001257590.1 NP_005876.2


NP_766194.2

Location (UCSC)

Chr 5: 10.35 – 10.44 Mb

Chr 15: 31.46 – 31.53 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.^[3]^[4]

See also

List of EC numbers (EC 3)

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
↑ "Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".

Further reading

Kreft SG, Wang L, Hochstrasser M (2006). "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI).". J. Biol. Chem. 281 (8): 4646–53. doi:10.1074/jbc.M512215200. PMID 16373356.
Hassink G, Kikkert M, van Voorden S, et al. (2005). "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.". Biochem. J. 388 (Pt 2): 647–55. doi:10.1042/BJ20041241. PMC 1138973. PMID 15673284.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Swanson R, Locher M, Hochstrasser M (2001). "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.". Genes Dev. 15 (20): 2660–74. doi:10.1101/gad.933301. PMC 312819. PMID 11641273.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

External links

MARCH6 human gene location in the UCSC Genome Browser.
MARCH6 human gene details in the UCSC Genome Browser.

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