MRPS35

MRPS35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS35, MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs	MGI: 2385255 HomoloGene: 11048 GeneCards: MRPS35
Gene ontology Molecular function • structural constituent of ribosome • poly(A) RNA binding Cellular component • cytoplasm • mitochondrial inner membrane • ribosome • intracellular ribonucleoprotein complex • mitochondrial small ribosomal subunit • mitochondrion Biological process • mitochondrial translational elongation • mitochondrial translational termination • DNA damage response, detection of DNA damage Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60488	232536
Ensembl	ENSG00000061794	ENSMUSG00000040112
UniProt	P82673	Q8BJZ4
RefSeq (mRNA)	NM_021821 NM_001190864	NM_145573
RefSeq (protein)	NP_001177793.1 NP_068593.2	NP_663548.2
Location (UCSC)	Chr 12: 27.71 – 27.76 Mb	Chr 6: 147.04 – 147.07 Mb
PubMed search	[1]	[2]
Wikidata

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.^[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.^[4]

References

Further reading