MCR-1

This article is about the antibiotic resistance mechanism. For the yeast gene, see Mcr1.
E. coli, the bacterium in which MCR-1 was first identified.

MCR-1 is a genetic mechanism by which the mcr-1 gene confers the first known plasmid-mediated resistance to colistin, a polymixin and one of a number of last-resort antibiotics.[1][2] The mechanism, first discovered in E. coli (strain SHP45) from a pig in China in November 2015, was later found by independent researchers in human samples from Malaysia, England,[3] China,[4] Europe[5] and the United States.[6] MCR-1 is the first known polymixin resistance mechanism capable of horizontal gene transfer.[1]

On 26 April 2016, a 49-year-old woman sought medical care at a Pennsylvania clinic for UTI symptoms. PCR of an E. coli isolate cultured from her urine revealed the first known presence of the mcr-1 gene in the United States.[7]

See also

References

  1. 1 2 Liu, YY; Wang, Y; Walsh, TR; Yi, LX; Zhang, R; Spencer, J; Doi, Y; Tian, G; Dong, B; Huang, X; Yu, LF; Gu, D; Ren, H; Chen, X; Lv, L; He, D; Zhou, H; Liang, Z; Liu, JH; Shen, J (18 November 2015). "Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.". The Lancet. Infectious diseases. 16: 161–8. doi:10.1016/S1473-3099(15)00424-7. PMID 26603172.
  2. ↑ Reardon, Sara (21 December 2015). "Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet". Nature. doi:10.1038/nature.2015.19037.
  3. ↑ "More MCR-1 findings lead to calls to ban ag use of colistin". Retrieved 2015-12-22.
  4. ↑ "Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study - The Lancet Infectious Diseases". www.thelancet.com. doi:10.1016/S1473-3099(15)00424-7. Retrieved 2015-11-19.
  5. ↑ Maryn McKenna. "Apocalypse Pig Redux: Last-Resort Resistance in Europe". Phenomena. Retrieved 28 May 2016.
  6. ↑ The U.S. Military HIV Research Program (MHRP). "First discovery in United States of colistin resistance in a human E. coli infection". www.sciencedaily.com. Retrieved 2016-05-27.
  7. ↑ "Highly resistant MCR-1 'superbug' found in US for first time". Retrieved 2016-08-09.


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