Myeong-Hee Yu

Myeong-Hee Yu
Born (1954-09-05) 5 September 1954
Seoul
Nationality South Korean
Alma mater Seoul National University
University of California, Berkeley
Occupation Microbiologist
Korean name
Hangul 유명희
Hanja 柳明姬[1]
Revised Romanization Yu Myeonghui
McCune–Reischauer Yu Myŏnghŭi
This is a Korean name; the family name is Yu.

Myeong-Hee Yu (born 5 September 1954) is a South Korean microbiologist. She has also been a scientific adviser to the President of South Korea.[2]

Biography

Yu was born in Seoul.[3] She realized that she was interested in science and technology when she was in middle school.[4] Yu's undergraduate work was conducted at Seoul National University and her doctorate was received from the University of California, Berkeley in 1981.[5] She later did postdoctoral fellow work at the Massachusetts Institute of Technology (MIT) in 1985.[3]

Much of Yu's work has focused on unlocking the structure and folding of the protein alpha-1 antitrypsin, which is a serpin protein.[6] She won a L'Oréal-UNESCO Award for Women in Science in 1998 for this work.[6] Yu and her research team have worked to discover what amino acids can suppress certain types of mutations, such as the tsf mutation which is a protein folding error.[7] She has also patented the alpha-1 antritrypsin mutein with a disulfide bond and the method for preparing it along with her research group.[8] Yu is the head of the 21st Century Frontier R&D Program at the Korea Institute of Science and Technology.[9]

Her work has appeared in Nature,[10] The Journal of Proteome Research,[11] the Proceedings of the National Academy of Sciences of the United States of America,[12] the Journal of Molecular Biology,[13] the Journal of Biological Chemistry,[14] the BMB Reports,[15] and others. Her work is highly cited in the fields of biochemistry, genetics, molecular biology, immunology and microbiology.[16]

In 2010, she was appointed to a new post in the South Korean government: senior officer for national future.[9] Her responsibilities included overseeing government communications regarding science and technology and to help promote low-carbon and green technologies.[17]

References

  1. ↑ 김창엽 [Gim Chang-yeop] (9 July 1998). "파워우먼: 생명공학연구소 유명희 박사" [Power woman: Dr. Yu Myeong-Hee, Research Institute of Biology and Biotechnology]. JoongAng Ilbo. Retrieved 3 November 2015.
  2. ↑ "Sydkorea – från snabb efterföljare till först i ledet". Vetandets värld (in Swedish). 3 July 2013. Retrieved 31 October 2015.
  3. 1 2 "Yu, Myeong-Hee". Korean Academy of Science and Technology. Retrieved 31 October 2015.
  4. ↑ Lee, Kye-Woo (2006). Advancement of Women in Science and Technology: A Case Study of Korea. Seoul, South Korea: Ewha Womans University Press. p. 196. ISBN 8973007033.
  5. ↑ "Myeong-Hee Yu". Gender Summits. Retrieved 31 October 2015.
  6. 1 2 "The L'Oreal – UNESCO Awards 1998 – 2011" (PDF). Retrieved 31 October 2015.
  7. ↑ Mitraki, Anna; Fane, Ben; Haase-Pettingell, Cameron; King, Jonathan (1991). "Mutations Affecting Protein Folding and Misfolding In Vivo". In Kelly, Jeffrey W.; Baldwin, Thomas O. Applications of Enzyme Biotechnology – Springer. Springer Science + Business Media. p. 134. doi:10.1007/978-1-4757-9235-5. ISBN 978-1-4757-9235-5.
  8. ↑ "Patents by Inventor Myeong-Hee Yu". Justia. Retrieved 31 October 2015.
  9. 1 2 Ser, Myo-ja (16 July 2010). "Lee Overhauls Blue House Staff". Korea JoongAng Daily. Retrieved 1 November 2015.
  10. ↑ Yu, Myeong-Hee; Lee, Kee Nyung; Kim, Jeongho (1995-05-01). "The Z type variation of human α1-antitrypsin causes a protein folding defect". Nature Structural & Molecular Biology. 2 (5): 363–367. doi:10.1038/nsb0595-363.
  11. ↑ Kim, Hye-Jung; Kang, Hyun Ju; Lee, Hanna; Lee, Seung-Taek; Yu, Myeong-Hee; Kim, Hoguen; Lee, Cheolju (2009-03-06). "Identification of S100A8 and S100A9 as Serological Markers for Colorectal Cancer". Journal of Proteome Research. 8 (3): 1368–1379. doi:10.1021/pr8007573. ISSN 1535-3893.
  12. ↑ Lee, Cheolju; Park, Soon-Ho; Lee, Min-Youn; Yu, Myeong-Hee (2000-07-05). "Regulation of protein function by native metastability". Proceedings of the National Academy of Sciences. 97 (14): 7727–7731. doi:10.1073/pnas.97.14.7727. ISSN 0027-8424. PMID 10884404.
  13. ↑ Yu, Myeong-Hee; Weissman, Jonathan S.; Kim, Peter S. (1995-01-01). "Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis". Journal of Molecular Biology. 249 (2): 388–397. doi:10.1006/jmbi.1995.0304.
  14. ↑ Kwon, K.S.; Kim, J; shin, H.S.; Yu, M.H. (1 April 1994). "Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability". The Journal of Biological Chemistry (269): 9627–9631. Retrieved 1 November 2015.
  15. ↑ Kim, Hye-Jung; Yu, Myeong-Hee; Kim, Ho-Guen; Byun, Jong-Hoe; Lee, Cheolju. "Noninvasive molecular biomarkers for the detection of colorectal cancer". BMB Reports. 41 (10): 685–692. doi:10.5483/bmbrep.2008.41.10.685.
  16. ↑ "Yu, Myeonghee". Scopus. Retrieved 1 November 2015.
  17. ↑ Kim, So-Hyun (15 July 2010). "Cable News Channel Executive Named Lee's PR Aide". The Korea Herald. Retrieved 1 November 2015.
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