N1-acetylpolyamine oxidase
| N1-acetylpolyamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.3.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N1-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2
- (2) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2
This enzyme also catalyses the reaction:
- N1,N12-diacetylspermine + O2 + H2O N1-acetylspermidine + 3-acetamamidopropanal + H2O2.
References
- ↑ Vujcic, S.; Liang, P.; Diegelman, P.; Kramer, D.L.; Porter, C.W. (2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". Biochem. J. 370: 19–28. doi:10.1042/BJ20021779. PMC 1223169
. PMID 12477380. - ↑ Jarvinen, A.; Grigorenko, N.; Khomutov, A.R.; Hyvonen, M.T.; Uimari, A.; Vepsalainen, J.; Sinervirta, R.; Keinanen, T.A.; Vujcic, S.; Alhonen, L.; Porter, C.W.; Janne, J. (2005). "Metabolic stability of α-methylated polyamine derivatives and their use as substitutes for the natural polyamines". J. Biol. Chem. 280 (8): 6595–6601. doi:10.1074/jbc.M412788200. PMID 15611107.
- ↑ Wang, Y.; Hacker, A.; Murray-Stewart, T.; Frydman, B.; Valasinas, A.; Fraser, A.V.; Woster, P.M.; Casero, R.A. Jr. (2005). "Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemother. Pharmacol. 56 (1): 83–90. doi:10.1007/s00280-004-0936-5. PMID 15791459.
- ↑ Wu, T.; Yankovskaya, V.; McIntire, W.S. (2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". J. Biol. Chem. 278: 20514–20525. doi:10.1074/jbc.M302149200. PMID 12660232.
External links
- N1-acetylpolyamine oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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