NAGPA

NAGPA
Identifiers
Aliases	NAGPA, Nagpa, AI596180, UCE, APAA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
External IDs	MGI: 1351598 HomoloGene: 8466 GeneCards: NAGPA
Gene ontology Molecular function • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity • hydrolase activity • protein binding Cellular component • integral component of membrane • Golgi cisterna membrane • Golgi apparatus • membrane Biological process • protein glycosylation • protein targeting to lysosome • lysosome organization • cellular protein modification process • carbohydrate metabolic process • secretion of lysosomal enzymes Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51172	27426
Ensembl	ENSG00000103174	ENSMUSG00000023143
UniProt	Q9UK23	Q8BJ48
RefSeq (mRNA)	NM_016256	NM_013796
RefSeq (protein)	NP_057340.2	NP_038824.2
Location (UCSC)	Chr 16: 5.02 – 5.03 Mb	Chr 16: 5.2 – 5.2 Mb
PubMed search	[1]	[2]
Wikidata

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene.^[3][4][5]

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.^[5]

References

Further reading