NDEL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2V66

Identifiers

Aliases

NDEL1, EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1

External IDs

MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1

Gene ontology
Molecular function	• protein complex binding • alpha-tubulin binding • protein binding • beta-tubulin binding • oligopeptidase activity • microtubule binding
Cellular component	• cytoplasm • cell body • condensed chromosome kinetochore • cytosol • neurofilament cytoskeleton • nuclear envelope • synaptic vesicle • spindle • chromosome • microtubule organizing center • microtubule associated complex • axon • cell leading edge • axon hillock • microtubule • chromosome, centromeric region • cytoskeleton • kinetochore • kinesin complex • centrosome • axon cytoplasm
Biological process	• retrograde axonal transport • cell differentiation • establishment of chromosome localization • activation of GTPase activity • chromosome segregation • neuron migration • positive regulation of axon regeneration • nervous system development • proteolysis • neuron projection extension • inner cell mass cell proliferation • multicellular organism development • regulation of intracellular protein transport • positive regulation of GTPase activity • establishment of mitotic spindle orientation • nuclear envelope disassembly • transport • positive regulation of axon extension • neurofilament cytoskeleton organization • cerebral cortex radially oriented cell migration • neuron projection development • microtubule cytoskeleton organization • microtubule nucleation • central nervous system neuron axonogenesis • regulation of neuron projection development • sister chromatid cohesion • centrosome localization • cell migration • mitotic centrosome separation • regulation of microtubule motor activity • vesicle transport along microtubule
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


81565


83431

Ensembl


ENSG00000166579


ENSMUSG00000018736

UniProt


Q9GZM8


Q9ERR1

RefSeq (mRNA)


NM_001025579 NM_030808


NM_023668

RefSeq (protein)


NP_001020750.1 NP_110435.1


NP_076157.2

Location (UCSC)

Chr 17: 8.41 – 8.49 Mb

Chr 11: 68.82 – 68.87 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[3]^[4]^[5]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]

Interactions

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[3] YWHAE,^[6] PAFAH1B1^[3]^[6] and DISC1.^[7]^[8]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Dec 2000). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron. 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260.
↑ Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Dec 2000). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron. 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259.
1 2 "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1".
1 2 Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
↑ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
↑ Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (Dec 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.
Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, Zhu X (Feb 2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle". Molecular and Cellular Biology. 23 (4): 1239–50. doi:10.1128/MCB.23.4.1239-1250.2003. PMC 141156. PMID 12556484.
Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (Apr 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ (Jan 2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders". Molecular and Cellular Neurosciences. 25 (1): 42–55. doi:10.1016/j.mcn.2003.09.009. PMID 14962739.
Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, Zhu X (Feb 2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein". The Journal of Cell Biology. 164 (4): 557–66. doi:10.1083/jcb.200308058. PMC 2171987. PMID 14970193.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A (Dec 2004). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase". Neuron. 44 (5): 809–21. doi:10.1016/j.neuron.2004.11.019. PMID 15572112.
Hayashi MA, Portaro FC, Bastos MF, Guerreiro JR, Oliveira V, Gorrão SS, Tambourgi DV, Sant'Anna OA, Whiting PJ, Camargo LM, Konno K, Brandon NJ, Camargo AC (Mar 2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3828–33. doi:10.1073/pnas.0500330102. PMC 553309. PMID 15728732.
Guerreiro JR, Winnischofer SM, Bastos MF, Portaro FC, Sogayar MC, de Camargo AC, Hayashi MA (Jul 2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation". Biochimica et Biophysica Acta. 1730 (1): 77–84. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.

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NDEL1

Interactions

References

Further reading