Product inhibition

Product inhibition is a type of enzyme inhibition where the product of an enzyme reaction binds to the enzyme and inhibits its activity.[1]

This can be important in the regulation of metabolism as a form of negative feedback controlling metabolic pathways.[2] Product inhibition is also an important topic in biotechnology, as overcoming this effect can increase the yield of a product, such as an antibiotic.[3]

References

  1. ↑ Walter C, Frieden E (1963). "The prevalence and significance of the product inhibition of enzymes". Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology - and Related Areas of Molecular Biology. 25: 167–274. doi:10.1002/9780470122709.ch4. ISBN 978-0-470-12270-9. PMID 14149677.
  2. ↑ Hutson NJ, Kerbey AL, Randle PJ, Sugden PH (1979). "Regulation of pyruvate dehydrogenase by insulin action". Prog. Clin. Biol. Res. 31: 707–19. PMID 231784.
  3. ↑ Schügerl K, Hubbuch J (2005). "Integrated bioprocesses". Curr. Opin. Microbiol. 8 (3): 294–300. doi:10.1016/j.mib.2005.01.002. PMID 15939352.
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