Pyronaridine

Pyronaridine
Clinical data

Routes of administration	Oral, intramuscular injection, intravenous therapy
ATC code	none
Legal status
Legal status	CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413)
Identifiers
IUPAC name 4-[(7-Chloro-2-methoxy-pyrido[3,2-b]quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
CAS Number	74847-35-1^N
PubChem (CID)	5485198
ChemSpider	10647812^Y
UNII	TD3P7Q3SG6^Y
ChEMBL	CHEMBL35228^Y
Chemical and physical data
Formula	C₂₉H₃₂ClN₅O₂
Molar mass	518.05 g/mol
3D model (Jmol)	Interactive image
SMILES Clc1ccc6c(c1)nc2ccc(OC)nc2c6Nc5cc(CN3CCCC3)c(O)c(CN4CCCC4)c5
InChI InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)^Y Key:DJUFPMUQJKWIJB-UHFFFAOYSA-N^Y
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Pyronaridine is an antimalarial drug. It was first synthesized in 1970 and has been in clinical use in China since the 1980s.^[1]

It is one of the components of the artemisinin combination therapy pyronaridine artesunate (Pyramax).

References

↑ Chang C, Lin-Hua T, Jantanavivat C (1992). "Studies on a new antimalarial compound: pyronaridine". Trans R Soc Trop Med Hyg. 86 (1): 7–10. doi:10.1016/0035-9203(92)90414-8. PMID 1566313.

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