RGS12

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2EBZ, 2KV8

Identifiers

Aliases

RGS12

External IDs

MGI: 1918979 HomoloGene: 2195 GeneCards: RGS12

Gene ontology
Molecular function	• signal transducer activity, downstream of receptor • GTPase regulator activity • GTPase activator activity
Cellular component	• cytoplasm • cell projection • nuclear matrix • synapse • condensed nuclear chromosome • cell junction • dendrite • nucleus • plasma membrane
Biological process	• regulation of G-protein coupled receptor protein signaling pathway • transcription, DNA-templated • positive regulation of GTPase activity • negative regulation of signal transduction • signal transduction • regulation of catalytic activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6002


71729

Ensembl


ENSG00000159788


ENSMUSG00000029101

UniProt


O14924


Q8CGE9

RefSeq (mRNA)

NM_002926 NM_198227 NM_198229 NM_198230 NM_198430
NM_198432 NM_198587


NM_001163512 NM_173402

RefSeq (protein)


NP_002917.1 NP_937870.1 NP_937872.1


NP_775578.2

Location (UCSC)

Chr 4: 3.29 – 3.44 Mb

Chr 5: 34.95 – 35.04 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[3]^[4]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[4]

Interactions

RGS12 has been shown to interact with GNAI1^[5] and GNAI3.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
1 2 "Entrez Gene: RGS12 regulator of G-protein signalling 12".
1 2 Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. United States. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.

Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue.". Ann. N. Y. Acad. Sci. 910: 85–104; discussion 104–5. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14.". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products.". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.". Nature. 408 (6813): 723–7. doi:10.1038/35047093. PMID 11130074.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
Snow BE, Brothers GM, Siderovski DP (2002). "Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain.". Meth. Enzymol. 344: 740–61. doi:10.1016/S0076-6879(02)44752-0. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression.". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability.". Genes Chromosomes Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.

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RGS12

Interactions

References

Further reading