SELS (gene)

VIMP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Q2F

Identifiers

Aliases

VIMP, ADO15, SBBI8, SELS, SEPS1, AD-015, VCP interacting membrane selenoprotein

External IDs

MGI: 95994 HomoloGene: 10200 GeneCards: VIMP

Gene ontology
Molecular function	• ATPase binding • antioxidant activity • protein binding • enzyme binding • ubiquitin-specific protease binding • receptor activity
Cellular component	• cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • Derlin-1-VIMP complex • plasma membrane • very-low-density lipoprotein particle • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • low-density lipoprotein particle • Derlin-1 retrotranslocation complex • cytoplasmic microtubule
Biological process	• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • regulation of gluconeogenesis • establishment of protein localization • negative regulation of interleukin-6 production • response to glucose • negative regulation of glycogen biosynthetic process • cell redox homeostasis • ER overload response • response to redox state • endoplasmic reticulum unfolded protein response • negative regulation of glucose import • retrograde protein transport, ER to cytosol • negative regulation of macrophage apoptotic process • ER-associated ubiquitin-dependent protein catabolic process • cellular response to insulin stimulus • regulation of nitric oxide metabolic process • cellular response to oxidative stress • negative regulation of tumor necrosis factor production • negative regulation of acute inflammatory response to antigenic stimulus • cellular response to lipopolysaccharide • intracellular protein transport • negative regulation of inflammatory response • negative regulation of nitric-oxide synthase biosynthetic process • cellular oxidant detoxification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55829


109815

Ensembl


ENSG00000131871


ENSMUSG00000075701

UniProt


Q9BQE4


Q9BCZ4

RefSeq (mRNA)


NM_203472 NM_018445


NM_024439

RefSeq (protein)


NP_060915.2 NP_982298.2


NP_077759.3

Location (UCSC)

Chr 15: 101.27 – 101.28 Mb

Chr 7: 66.08 – 66.09 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Selenoprotein S, also known as SELS, is a human gene.^[3]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

SELS (gene) has been shown to interact with Valosin-containing protein.^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: SELS selenoprotein S".
↑ Ye, Yihong; Shibata Yoko; Yun Chi; Ron David; Rapoport Tom A (Jun 2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. England. 429 (6994): 841–7. doi:10.1038/nature02656. PMID 15215856.
↑ Wang, Qiuyan; Li Lianyun; Ye Yihong (Mar 2008). "Inhibition of p97-dependent Protein Degradation by Eeyarestatin I". J. Biol. Chem. United States. 283 (12): 7445–54. doi:10.1074/jbc.M708347200. ISSN 0021-9258. PMC 2276333. PMID 18199748.

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Walder K, Kantham L, McMillan JS, et al. (2002). "Tanis: a link between type 2 diabetes and inflammation?". Diabetes. 51 (6): 1859–66. doi:10.2337/diabetes.51.6.1859. PMID 12031974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gao Y, Walder K, Sunderland T, et al. (2003). "Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells". Diabetes. 52 (4): 929–34. doi:10.2337/diabetes.52.4.929. PMID 12663463.
Kryukov GV, Castellano S, Novoselov SV, et al. (2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gao Y, Feng HC, Walder K, et al. (2004). "Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein". FEBS Lett. 563 (1–3): 185–90. doi:10.1016/S0014-5793(04)00296-0. PMID 15063746.
Karlsson HK, Tsuchida H, Lake S, et al. (2004). "Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects". Diabetes. 53 (6): 1424–8. doi:10.2337/diabetes.53.6.1424. PMID 15161744.
Ye Y, Shibata Y, Yun C, et al. (2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. 429 (6994): 841–7. doi:10.1038/nature02656. PMID 15215856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lilley BN; Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–301. doi:10.1073/pnas.0505014102. PMC 1242303. PMID 16186509.
Ye Y, Shibata Y, Kikkert M, et al. (2006). "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14132–8. doi:10.1073/pnas.0505006102. PMC 1242302. PMID 16186510.
Curran JE, Jowett JB, Elliott KS, et al. (2006). "Genetic variation in selenoprotein S influences inflammatory response". Nat. Genet. 37 (11): 1234–41. doi:10.1038/ng1655. PMID 16227999.
Gao Y, Hannan NR, Wanyonyi S, et al. (2006). "Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells". Cytokine. 33 (5): 246–51. doi:10.1016/j.cyto.2006.02.005. PMID 16574427.
Gao Y, Pagnon J, Feng HC, et al. (2007). "Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells". Biochem. Biophys. Res. Commun. 356 (3): 636–41. doi:10.1016/j.bbrc.2007.03.018. PMID 17374524.
Seiderer J, Dambacher J, Kühnlein B, et al. (2007). "The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation". Tissue Antigens. 70 (3): 238–46. doi:10.1111/j.1399-0039.2007.00888.x. PMID 17661913.

PDB gallery

2q2f: Structure of the human Selenoprotein S (VCP-interacting membrane protein)

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SELS (gene)

Interactions

References

Further reading