SEMA4F

SEMA4F

Identifiers

SEMA4F, M-SEMA, PRO2353, S4F, SEMAM, SEMAW, m-Sema-M, ssemaphorin 4F

External IDs

MGI: 1340055 HomoloGene: 3147 GeneCards: SEMA4F

Gene ontology
Molecular function	• semaphorin receptor binding • neuropilin binding • chemorepellent activity
Cellular component	• integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • extracellular fluid • endoplasmic reticulum
Biological process	• cell differentiation • negative chemotaxis • positive regulation of cell migration • cell-cell signaling • nervous system development • negative regulation of axon extension involved in axon guidance • axon guidance • multicellular organism development • neural crest cell migration • negative regulation of axon extension • semaphorin-plexin signaling pathway • retinal ganglion cell axon guidance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


10505


20355


ENSG00000135622


ENSMUSG00000000627


O95754


Q9Z123

RefSeq (mRNA)


NM_001271661 NM_001271662 NM_004263


NM_001113481 NM_011350 NM_001308374

RefSeq (protein)


NP_001258590.1 NP_001258591.1 NP_004254.2


NP_035480.3

Location (UCSC)

Chr 2: 74.65 – 74.68 Mb

Chr 6: 82.91 – 82.94 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Semaphorin-4F is a protein that in humans is encoded by the SEMA4F gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Encinas JA; Kikuchi K; Chedotal A; de Castro F; Goodman CS; Kimura T (Apr 1999). "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family". Proc Natl Acad Sci U S A. 96 (5): 2491–6. doi:10.1073/pnas.96.5.2491. PMC 26812. PMID 10051670.
↑ "Entrez Gene: SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F".

Further reading

Giger RJ, Urquhart ER, Gillespie SK, et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
Hartley JL; Temple GF; Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Schultze W, Eulenburg V, Lessmann V, et al. (2001). "Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95". J. Neurochem. 78 (3): 482–9. doi:10.1046/j.1471-4159.2001.00447.x. PMID 11483650.
Francks C, Fisher SE, Olson RK, et al. (2002). "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1". Psychiatr. Genet. 12 (1): 35–41. doi:10.1097/00041444-200203000-00005. PMID 11901358.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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