SH2D3A

Identifiers

SH2D3A, NSP1, SH2 domain containing 3A

External IDs

Gene ontology
Molecular function	• protein binding • SH3/SH2 adaptor activity • guanyl-nucleotide exchange factor activity
Cellular component	• intracellular
Biological process	• small GTPase mediated signal transduction • JNK cascade • positive regulation of GTPase activity • positive regulation of signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10045


n/a

Ensembl


ENSG00000125731


n/a

UniProt


Q9BRG2


n/a

RefSeq (mRNA)


NM_005490


n/a

RefSeq (protein)


NP_005481.2


n/a

Location (UCSC)

Chr 19: 6.75 – 6.77 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene.^[2]^[3]

Interactions

SH2D3A has been shown to interact with Epidermal growth factor receptor.^[2]

References

↑ "Human PubMed Reference:".
1 2 Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
↑ "Entrez Gene: SH2D3A SH2 domain containing 3A".

Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A (Sep 2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". Journal of Cellular Physiology. 212 (3): 655–65. doi:10.1002/jcp.21059. PMC 2640322. PMID 17427198.
Vervoort VS, Roselli S, Oshima RG, Pasquale EB (Apr 2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene. 391 (1-2): 161–70. doi:10.1016/j.gene.2006.12.016. PMC 1876674. PMID 17270363.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

SH2D3A human gene location in the UCSC Genome Browser.
SH2D3A human gene details in the UCSC Genome Browser.

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SH2D3A

Interactions

References

Further reading

External links