SNRPB2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A9N

Identifiers

Aliases

SNRPB2, Msl1, U2B, small nuclear ribonucleoprotein polypeptide B2

External IDs

MGI: 104805 HomoloGene: 37728 GeneCards: SNRPB2

Gene ontology
Molecular function	• nucleic acid binding • nucleotide binding • snRNA stem-loop binding • protein binding • RNA binding • snRNP binding
Cellular component	• catalytic step 2 spliceosome • spliceosomal complex • intracellular ribonucleoprotein complex • nucleolus • nucleus • U2 snRNP • nucleoplasm • small nuclear ribonucleoprotein complex
Biological process	• mRNA splicing, via spliceosome • mRNA processing • xenophagy • positive regulation of defense response to virus by host • RNA splicing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6629


20639

Ensembl


ENSG00000125870


ENSMUSG00000008333

UniProt


P08579


Q9CQI7

RefSeq (mRNA)


NM_198220 NM_003092


NM_021335

RefSeq (protein)


NP_003083.1 NP_937863.1


NP_067310.1

Location (UCSC)

Chr 20: 16.73 – 16.74 Mb

Chr 2: 143.06 – 143.07 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.^[3]^[4]

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739.
1 2 "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins.". J. Cell Biol. 110 (4): 871–81. doi:10.1083/jcb.110.4.871. PMC 2116108. PMID 2139037.
Laitinen J, Saris P, Hölttä E, Pettersson I (1995). "U2-snRNP B" protein gene is an early growth-inducible gene.". J. Cell. Biochem. 58 (4): 490–8. doi:10.1002/jcb.240580412. PMID 7593271.
Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMC 146436. PMID 9016565.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles.". Biochem. J. 332 (1): 135–44. PMC 1219461. PMID 9576861.
Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.". Nature. 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II.". J. Cell Biol. 152 (1): 75–85. doi:10.1083/jcb.152.1.75. PMC 2193649. PMID 11149922.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process.". Biochim. Biophys. Acta. 1576 (3): 287–97. doi:10.1016/S0167-4781(02)00368-8. PMID 12084575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

1a9n: CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA

RNA-binding protein: Ribonucleoproteins

snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 C L R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

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SNRPB2

References

Further reading