SNX2

SNX2
Identifiers
Aliases SNX2, TRG-9, sorting nexin 2
External IDs MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

6643

67804

Ensembl

ENSG00000205302

ENSMUSG00000034484

UniProt

O60749

Q9CWK8

RefSeq (mRNA)

NM_003100
NM_001278199

NM_026386

RefSeq (protein)

NP_001265128.1
NP_003091.2

NP_080662.1

Location (UCSC) Chr 5: 122.77 – 122.83 Mb Chr 18: 53.18 – 53.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[3][4]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[4]

Interactions

SNX2 has been shown to interact with FNBP1.[5][6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309Freely accessible. PMID 9819414.
  4. 1 2 "Entrez Gene: SNX2 sorting nexin 2".
  5. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1-2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
  6. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508Freely accessible. PMID 11438682.

Further reading


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