Segmental duplication
Segmental duplications (SDs) are segments of DNA with near-identical sequence.[1]
Segmental duplications give rise to low copy repeats (LCRs) and are believed to have played a role in creating new primate genes as reflected in human genetic variation. In humans, chromosomes Y and 22 have the greatest proportion of SDs: 50.4% and 11.9% respectively.[2]
Detection method
The two widely accepted methods for SD detection are whole genome assembly comparison (WGAC) and whole genome shotgun sequence detection (WSSD).
See also
- Copy number variation
- Pseudogenes
- Molecular evolution
- Human genome
- Comparative genomics
- Inparanoid
- Tandem exon duplication
References
- ↑ Genome-wide detection of segmental duplications
- ↑ Bailey, Jeffrey A.; Eichler, EE (2006). "Primate segmental duplications: crucibles of evolution, diversity and disease". Nature Reviews Genetics. 7 (7): 552–64. doi:10.1038/nrg1895. PMID 16770338.
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