Small Cajal body specific RNA 15
| Small Cajal body specific RNA 15 | |
|---|---|
 Predicted secondary structure and sequence conservation of SCARNA15 | |
| Identifiers | |
| Symbol | SCARNA15 |
| Alt. Symbols | snoACA45 |
| Rfam | RF00426 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA |
| Domain(s) | Eukaryota |
| GO | 0006396 0015030 0005730 |
| SO | 0000275 |
Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
ACA45 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[2] ACA45 is predicted to guide the pseudouridylation of residue U37 of the U2 spliceosomal snRNA.[3]
It has been shown that human ACA45 can be processed into a 21 nucleotides long mature miRNA by the RNAse III family endoribonuclease dicer.[4] This snoRNA product has previously been identified as mmu-miR-1839[5] and was shown to be processed independent of the other miRNA generating endoribonuclease drosha.[6]
References
- ↑ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017
. PMID 12032087. - ↑ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ↑ Ender, C.; Krek, A.; Friedländer, M.; Beitzinger, M.; Weinmann, L.; Chen, W.; Pfeffer, S.; Rajewsky, N.; Meister, G. (2008). "A human snoRNA with microRNA-like functions". Molecular Cell. 32 (4): 519–528. doi:10.1016/j.molcel.2008.10.017. PMID 19026782.
- ↑ "mmu-miR-1839". MiRBase.
- ↑ Babiarz, J.; Ruby, J.; Wang, Y.; Bartel, D.; Blelloch, R. (2008). "Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs". Genes & Development. 22 (20): 2773–2785. doi:10.1101/gad.1705308. PMC 2569885. PMID 18923076.