TTC3

TTC3

Identifiers

TTC3, DCRR1, RNF105, TPRDIII, tetratricopeptide repeat domain 3

External IDs

MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3

Gene ontology
Molecular function	• zinc ion binding • ligase activity • protein binding • metal ion binding • ubiquitin-protein transferase activity
Cellular component	• cytoplasm • nucleolus • nucleus
Biological process	• protein K48-linked ubiquitination • protein ubiquitination • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


7267


22129


ENSG00000182670


ENSMUSG00000040785


P53804


O88196

RefSeq (mRNA)


NM_001001894 NM_003316 NM_001320703 NM_001320704


NM_009441

RefSeq (protein)


NP_001001894.1 NP_003307.3 NP_001307633.1

XP_011249721.1 XP_011249722.1 XP_011249724.1 XP_011249725.1 XP_011249730.1
XP_011249731.1 XP_011249732.1 XP_011249733.1

Location (UCSC)

Chr 21: 37.07 – 37.2 Mb

Chr 16: 94.37 – 94.47 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem. 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
↑ "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Further reading

Ohira M, Ootsuyama A, Suzuki E, et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
Eki T, Abe M, Naitou M, et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Rachidi M, Lopes C, Gassanova S, et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berto G, Camera P, Fusco C, et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell. Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.

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