UQCRH

UQCRH

Identifiers

UQCRH, QCR6, UQCR8, ubiquinol-cytochrome c reductase hinge protein

External IDs

MGI: 3641869 HomoloGene: 103848 GeneCards: UQCRH

Gene ontology
Molecular function	• ubiquinol-cytochrome-c reductase activity • protein binding
Cellular component	• mitochondrial inner membrane • respiratory chain • membrane • mitochondrion • mitochondrial respiratory chain
Biological process	• aerobic respiration • oxidative phosphorylation • oxidation-reduction process • hydrogen ion transmembrane transport • mitochondrial electron transport, ubiquinol to cytochrome c
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


7388


100042918


ENSG00000173660


n/a


P07919


n/a

RefSeq (mRNA)


NM_006004 NM_001297565 NM_001297566


n/a

RefSeq (protein)


NP_005995.2


n/a

Location (UCSC)

Chr 1: 46.3 – 46.32 Mb

n/a

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^[3]^[4]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett. 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.
↑ "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein".

Further reading

Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer.". Cancer Res. 53 (11): 2460–5. PMID 7684318.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene. 22 (29): 4586–93. doi:10.1038/sj.onc.1206472. PMID 12881716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1bcc: CYTOCHROME BC1 COMPLEX FROM CHICKEN

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

1sqb: Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin

1sqp: Crystal Structure Analysis of Bovine Bc1 with Myxothiazol

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2bcc: STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

3bcc: STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

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