ZFYVE27
| View/Edit Human | View/Edit Mouse |
Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene. [3]
Function
This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neuriteformation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism (biology), is unclear. [provided by RefSeq, Mar 2010].
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: Zinc finger, FYVE domain containing 27". Retrieved 2014-02-23.
Further reading
- Zhang, C; Li, D; Ma, Y; Yan, J; Yang, B; Li, P; Yu, A; Lu, C; Ma, X (2012). "Role of spastin and protrudin in neurite outgrowth". Journal of Cellular Biochemistry. 113 (7): 2296–307. doi:10.1002/jcb.24100. PMID 22573551.
- Saita, S; Shirane, M; Natume, T; Iemura, S; Nakayama, K. I. (2009). "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein". Journal of Biological Chemistry. 284 (20): 13766–77. doi:10.1074/jbc.M807938200. PMC 2679478
. PMID 19289470. - Mannan, A. U.; Krawen, P; Sauter, S. M.; Boehm, J; Chronowska, A; Paulus, W; Neesen, J; Engel, W (2006). "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia". The American Journal of Human Genetics. 79 (2): 351–7. doi:10.1086/504927. PMC 1559503. PMID 16826525.
- Martignoni, M; Riano, E; Rugarli, E. I. (2008). "The role of ZFYVE27/protrudin in hereditary spastic paraplegia". The American Journal of Human Genetics. 83 (1): 127–8; author reply 128–30. doi:10.1016/j.ajhg.2008.05.014. PMC 2443834. PMID 18606302.
- Matsuzaki, F; Shirane, M; Matsumoto, M; Nakayama, K. I. (2011). "Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation". Molecular Biology of the Cell. 22 (23): 4602–20. doi:10.1091/mbc.E11-01-0068. PMC 3226478. PMID 21976701.
- Shirane, M; Nakayama, K. I. (2006). "Protrudin induces neurite formation by directional membrane trafficking". Science. 314 (5800): 818–21. doi:10.1126/science.1134027. PMID 17082457.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.