3-mercaptopyruvate sulfurtransferase

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3-mercaptopyruvate:cyanide sulfurtransferase. This enzyme is also called beta-mercaptopyruvate sulfurtransferase. This enzyme participates in cysteine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1OKG and 1URH.

References

Fiedler H; Wood JL (1956). "Specificity studies on the beta-mercaptopyruvate-cyanide transsulfuration system". J. Biol. Chem. 222 (1): 387–397. PMID 13367011.
HYLIN JW; WOOD JL (1959). "Enzymatic formation of polysulfides from mercaptopyruvate". J. Biol. Chem. 234 (8): 2141–4. PMID 13673028.
Sorbo BH (1957). "Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates". Biochem. Biophys. Acta. 24: 324–329. doi:10.1016/0006-3002(57)90201-9.
Vachek H; Wood JL (1972). "Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli". Biochim. Biophys. Acta. 258 (1): 133–46. doi:10.1016/0005-2744(72)90973-4. PMID 4550801.
Van den Hamer CJ; Morell AG; Scheinberg IH (1967). "A study of the cooper content of beta-mercaptopyruvate trans-sulfurase". J. Biol. Chem. 242 (10): 2514–6. PMID 6026243.

Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase

2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase

2.8.3: CoA-transferases	Propionate CoA-transferase

2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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