List of progestogens available in the United States
This is a complete list of progestogens (progesterone and progestins) and formulations that are approved by the FDA and available in the United States. Progestogens are used as hormonal contraceptives, in hormone replacement therapy for menopausal symptoms, and in the treatment of gynecological disorders.
For contraception
Main articles: Hormonal contraception and Birth control
Combined contraceptives
Combined oral contraceptive pills
Main article: Combined oral contraceptive pill
- Estradiol valerate and dienogest (Natazia)
- Ethinyl estradiol and desogestrel (Bekyree, Cyclessa, Desogen, Emoquette, Enskyce, Isibloom, Kariva, Kimidess, Mircette, Ortho-Cept, Pimtrea, Velivet, Viorele, Volnea)
- Ethinyl estradiol and drospirenone [and/or levomefolate calcium] (Beyaz, Loryna, Melamisa, Nikki, Safyral, Syeda, Yaela, Yasmin, Yaz)
- Ethinyl estradiol and etynodiol diacetate (Demulen 1/35-21, Demulen 1/35-28, Demulen 1/50-21, Demulen 1/50-28, Kelnor, Zovia 1/35E-21, Zovia 1/35E-28, Zovia 1/50E-21, Zovia 1/50E-28)
- Ethinyl estradiol and levonorgestrel (Alesse, Altavera, Ashlyna, Aviane-21, Aviane-28, Ayuna, Daysee, Elifemme, Enpresse-21, Enpresse-28, Falmina, Fayosim, Introvale, Kurvelo, Lessina-21, Lessina-28, Levlite, Levonest, Levonorgestrel and Ethinyl Estradiol, Levora 0.15/30-21, Levora 0.15/30-28, LoSeasonique, Lybrel, Marlissa, Myzilra, Nordette-21, Nordette-28, Orsythia, Portia-21, Portia-28, Preven Emergency Contraceptive Kit, Quartette, Quasense, Seasonale, Seasonique, Setlakin, Triphasil-21, Triphasil-28, Trivora-21, Trivora-28, Vienva)
- Ethinyl estradiol and norethisterone [and/or ferrous fumarate (Fe)] (Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Aranelle, Balziva-21, Balziva-28, Brevicon 21-Day, Brevicon 28-Day, Briellyn, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Dasetta 1/35, Dasetta 7/7/7, Femcon Fe, Gencept 10/11-21, Gencept 10/11-28, Gildagia, Kaitlib Fe, Modicon 21, Modicon 28, N.E.E. 1/35 21, N.E.E. 1/35 28, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
- Ethinyl estradiol and norethisterone acetate [and/or ferrous fumarate (Fe)] (Blisovi 24 Fe, Blisovi Fe 1.5/30, Blisovi Fe 1/20, Estrostep 21, Estrostep Fe, Fyavolv, Gildess 1.5/30, Gildess 1/20, Gildess 24 Fe, Gildess Fe 1.5/30, Gildess Fe 1/20, Junel 1.5/30, Junel 1/20, Junel Fe 1.5/30, Junel Fe 1/20, Larin 1.5/30, Larin 1/20, Larin 24 Fe, Larin Fe 1.5/30, Larin Fe 1/20, Leribane, Lo Loestrin Fe, Lo Minastrin Fe, Lo-Blisovi Fe, Loestrin 21 1.5/30, Loestrin 21 1/20, Loestrin 24 Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20, Mibelas 24 Fe, Microgestin 1.5/30, Microgestin Fe 1/20, Minastrin 24 Fe, Norlestrin 21 1/50, Norlestrin 21 2.5/50, Norlestrin 28 1/50, Norlestrin Fe 1/50, Norlestrin Fe 2.5/50, Taytulla, Tri-Legest 21, Tri-Legest Fe)
- Ethinyl estradiol and norgestimate (Estarylla, Mili, Mono-Linyah, Ortho Cyclen-21, Ortho Cyclen-28, Ortho Tri-Cyclen, Ortho Tri-Cyclen 21, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Previfem, Sprintec, Tri Lo Sprintec, Tri-Estarylla, Tri-Linyah, Tri-Lo-Estarylla, Tri-Lo-Linyah, Tri-Mili, Tri-Previfem, Tri-Sprintec)
- Ethinyl estradiol and norgestrel (Cryselle, Elinest, Lo/Ovral, Lo/Ovral-28, Low-Ogestrel-21, Low-Ogestrel-28, Ogestrel 0.5/50-21, Ogestrel 0.5/50-28, Ovral, Ovral-28)
- Mestranol and norethisterone (Norinyl 1+50 28-Day)
Discontinued:
- Ethinyl estradiol and dimethisterone (Oracon, Oracon 28)
- Ethinyl estradiol and medroxyprogesterone acetate (Provest)
- Mestranol and chlormadinone acetate (C-Quens, Estalor)
- Mestranol and etynodiol diacetate (Ovulen, Ovulen-21, Ovulen-28)
- Mestranol and norethisterone (Norethin 1/50M-21, Norethin 1/50M-28, Noriday, Norinyl, Norinyl 1+50 21-Day, Norinyl 1+80 21-Day, Norinyl 1+80 28-Day, Norquen, Ortho-Novum 1/50 21, Ortho-Novum 1/50 28, Ortho-Novum 1/80 21, Ortho-Novum 1/80 28, Ortho-Novum 10-21, Ortho-Novum 2-21)
- Mestranol and noretynodrel (Enovid, Enovid-E, Enovid-E 21)
Transdermal patches
Main article: Contraceptive patch
- Ethinyl estradiol and norelgestromin (Ortho Evra, Xulane)
Vaginal rings
Main articles: Vaginal ring and Contraceptive vaginal ring
Combined injectable contraceptives
Main article: Combined injectable contraceptive
Discontinued:
- Estradiol cypionate and medroxyprogesterone acetate (Lunelle) – 5 mg / 25 mg
Progestogen-only contraceptives
Main article: Progestogen-only contraception
Progestogen-only pills
Main article: Progestogen-only pill
- Norethisterone (Camila, Errin, Heather, Incassia, Jencycla, Micronor, Nor-QD) – 0.35 mg
Discontinued:
- Norgestrel (Ovrette) – 0.075 mg oral pills
Postcoital emergency contraceptive pills
Main article: Emergency contraception
- Levonorgestrel (Athentia Next, Fallback Solo, Her Style, Opcicon One-Step, Plan B, Plan B One-Step) – 0.75 mg, 1.5 mg
Progestogen-only injectable contraceptives
Main article: Progestogen-only injectable contraceptive
- Medroxyprogesterone acetate (Depo-Provera) – 150 mg/mL (intramuscular)
- Medroxyprogesterone acetate (Depo-SubQ Provera 104) – 104 mg/0.65 mL (subcutaneous)
Intrauterine devices
- Levonorgestrel (Kyleena, Liletta, Mirena, Skyla) – 13.5 mg/device, 19.5 mg/device, 52 mg/device
Discontinued:
- Progesterone (Progestasert) – 38 mg/device
Subdermal implants
Main articles: Contraceptive implant, Etonogestrel contraceptive implant, and Long-acting reversible contraception
- Etonogestrel (Implanon, Nexplanon) – 68 mg/implant
- Levonorgestrel (Jadelle, Norplant, Norplant System in Plastic Container) – 36 mg/implant, 75 mg/implant
For gynecological disorders, menopausal symptoms, and other conditions
Main articles: Hormone replacement therapy and Hormone replacement therapy (menopause)
Combined with estrogen
Oral pills
- Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg
- Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg
- Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg
- Ethinyl estradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg
Discontinued:
- Estradiol and norgestimate (Prefest) – 1 mg / 90 μg
Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone, is under development.[1]
Transdermal patches
- Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
- Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours
Progestogen-only
Oral pills
- Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) – 2.5 mg, 5 mg, 10 mg
- Megestrol acetate (Megace) – 20 mg, 40 mg – approved specifically for the treatment of breast and endometrial cancer[2] and for the treatment of anorexia, cachexia, and weight loss in patients with AIDS[3]
- Norethisterone acetate (Aygestin, Norlutate) – 5 mg
- Progesterone (Prometrium) – 100 mg, 200 mg, 300 mg
Atypical:
- Danazol (Danocrine) – 50 mg, 100 mg, 200 mg – approved specifically for the treatment of endometriosis
Discontinued:
- Dydrogesterone (Duphaston, Gynorest)[4] – 5 mg, 10 mg
- Ethisterone (Pranone) – 5 mg, 10 mg, 25 mg[5]
- Hydroxyprogesterone acetate (Prodox) – 25 mg, 50 mg
- Medrogestone (Colprone)[6] – 5 mg
- Norethisterone (Norlutin) – 5 mg
Oral suspensions
- Megestrol acetate (Megace, Megace ES) – 40 mg/mL, 125 mg/mL – approved specifically for the treatment of anorexia, cachexia, and weight loss in patients with AIDS
Vaginal gels
- Progesterone (Crinone, Progestasert, Prometrium) – 4%, 8%
Vaginal inserts
- Progesterone (Endometrin) – 100 mg
Intramuscular injectables
- Hydroxyprogesterone caproate (Delalutin, Makena, Makena Preservative Free) – 125 mg/mL, 250 mg/mL
- Medroxyprogesterone acetate (Depo-Provera) – 400 mg/mL – approved specifically for the treatment of endometrial/renal cancer
- Progesterone (Progesterone) – 50 mg/mL
Discontinued:
- Progesterone (Progesterone) – 25 mg/mL
Miscellaneous
- Norethisterone acetate and leuprorelin (Lupaneta Pack) – 5 mg norethisterone acetate oral pills, 3.75 mg/vial, 11.25 mg/vial leuprorelin for intramuscular injection – approved specifically for the treatment of painful endometriosis
Progestogens not available in the United States
- Acetomepregenol
- Algestone
- Algestone acetophenide
- Allylestrenol
- Chlormadinone acetate
- Cyproterone acetate
- Demegestone
- Dimethisterone
- Dydrogesterone
- Ethisterone
- Gestodene
- Gestonorone caproate
- Gestrinone
- Haloprogesterone
- Hydroxyprogesterone
- Hydroxyprogesterone acetate
- Hydroxyprogesterone heptanoate
- Lynestrenol
- Medrogestone
- Nomegestrol acetate
- Norethisterone enanthate
- Noretynodrel
- Norgesterone
- Norgestrienone
- Normethandrone
- Norvinisterone
- Oxendolone
- Pentagestrone acetate
- Promegestone
- Quingestanol acetate
- Quingestrone
- Segesterone acetate (nestorone)
- Tibolone
- Trengestone
- Trimegestone
See also
- List of estrogens available in the United States
- List of androgens/anabolic steroids available in the United States
- List of steroidal progestogens
- Progestogen ester
- Oral contraceptive formulations
- Estradiol-containing oral contraceptive
Notes
- ↑ Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B (2015). "Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy". Menopause. 22 (12): 1308–16. doi:10.1097/GME.0000000000000467. PMC 4666011
. PMID 25944519. - ↑ Jame Abraham; James L. Gulley; Carmen J. Allegra (1 September 2009). Bethesda Handbook of Clinical Oncology. Lippincott Williams & Wilkins. pp. 612–. ISBN 978-0-7817-9558-6.
- ↑ Guido Eibl; Mouad Edderkaoui (22 April 2015). Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets. Frontiers Media SA. pp. 96–. ISBN 978-2-88919-468-1.
In 1993, the Food and Drug Administration (FDA) approved megestrol acetate for the treatment of cancer anorexia-cachexia syndrome as well as cachexia due to chronic conditions, including human acquired immunodeficiency syndrome (AIDS).
- ↑ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 1411–. ISBN 978-0-8155-1856-3.
- ↑ Journal of the American Medical Women's Association. American Medical Women's Association. 1948. p. 354.
Packaging: Pranone (anhydrohydroxy-progesterone) Tablets of 5, 10 or 25 mg., in boxes of 20, 40, 100 and 250 tablets.
- ↑ Revesz C, Chappel CI (1966). "Biological activity of medrogestone: a new orally active progestin". J. Reprod. Fertil. 12 (3): 473–87. PMID 4288903.
References
- "Drugs@FDA: FDA Approved Drug Products" (HTML). United States Food and Drug Administration. Retrieved 16 November 2016.
- "DailyMed" (HTML). National Institutes of Health: United States National Library of Medicine. Retrieved 12 October 2016.
External links
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