NLRP1

NLRP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases NLRP1, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1, NLR family, pyrin domain containing 1, NLR family pyrin domain containing 1
External IDs MGI: 3582959 HomoloGene: 19080 GeneCards: NLRP1
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

22861

637515

Ensembl

ENSG00000091592

ENSMUSG00000070390

UniProt

Q9C000

Q2LKV5
Q2LKV2
Q2LKW6
Q0GKD5

RefSeq (mRNA)

NM_033007
NM_001033053
NM_014922
NM_033004
NM_033006

NM_001039680
NM_001040696
NM_001162414

RefSeq (protein)

NP_001028225.1
NP_055737.1
NP_127497.1
NP_127499.1
NP_127500.1

NP_001035786.1
NP_001155886.1

Location (UCSC) Chr 17: 5.5 – 5.62 Mb Chr 11: 71.15 – 71.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

NACHT, LRR and PYD domains-containing protein 1 is a protein that in humans is encoded by the NLRP1 gene.[3][4][5]

Function

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. The NLRP1 protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.[5]

Interactions

NLRP1 has been shown to interact with caspase 9[6][7] and APAF1.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S (Oct 1996). "Phylogeny and structure of the RING3 gene". Immunogenetics. 44 (5): 391–6. doi:10.1007/BF02602785. PMID 8781126.
  4. Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
  5. 1 2 "Entrez Gene: NLRP1 NLR family, pyrin domain containing 1".
  6. 1 2 Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (Mar 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". J. Biol. Chem. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
  7. Hlaing T, Guo RF, Dilley KA, Loussia JM, Morrish TA, Shi MM, Vincenz C, Ward PA (Mar 2001). "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins". J. Biol. Chem. 276 (12): 9230–8. doi:10.1074/jbc.M009853200. PMID 11076957.

Further reading


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