NLRP8

NLRP8
Identifiers
Aliases NLRP8, CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8
External IDs HomoloGene: 82360 GeneCards: NLRP8
Genetically Related Diseases
obesity[1]
Orthologs
Species Human Mouse
Entrez

126205

n/a

Ensembl

ENSG00000179709

n/a

UniProt

Q86W28

n/a

RefSeq (mRNA)

NM_176811
NM_001317000

n/a

RefSeq (protein)

NP_789781.2
NP_001303929.1

n/a

Location (UCSC) Chr 19: 55.95 – 55.99 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.[3][4] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

  1. "Diseases that are genetically associated with NLRP8 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045.
  4. Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741Freely accessible. PMID 19682372.

Further reading

  • Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
  • Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. 
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 


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