Small nucleolar RNA SNORD50

Small nucleolar RNA SNORD50

Identifiers
Symbol SNORD50
Alt. Symbols U50
Rfam RF00278
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U50 (also known as SNORD50) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U50 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

U50 is an intronic snoRNA gene located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). The U50HG gene is composed of six exons, whose spliced transcripts have little potential for coding a protein, and its introns produce both U50 and U50-like (U50') snoRNAs that are localised in nucleoli.[3] There is evidence that the U50 paralogues form a novel family of genes controlling oncogenesis and sensitivity to therapy in cancer.[4][5]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523.
  2. ↑ Kiss-Laszlo, Z; Henry Y; Bachellerie JP; Caizergues-Ferrer M; Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.
  3. ↑ Tanaka, R; Satoh H; Moriyama M; Satoh K; Morishita Y; Yoshida S; Watanabe T; Nakamura Y; Mori S (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes Cells. 5 (4): 277–287. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.
  4. ↑ Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (October 2008). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484.
  5. ↑ Dong XY, Guo P, Boyd J, et al. (August 2009). "Implication of snoRNA U50 in human breast cancer". J Genet Genomics. 36 (8): 447–54. doi:10.1016/S1673-8527(08)60134-4. PMC 2854654Freely accessible. PMID 19683667.


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