Spiroindolone

The spiroindolones are an emerging class of antimalarial drugs[1] whose mode of action is to inhibit protein synthesis in the target parasite. In the September 2010 edition of Science, Rottmann et al. reported the development of a successful anti-malarial spiroindolone: NITD609.[2]

References

  1. ↑ Yeung, Bryan K. S.; Bin Zou, Matthias Rottmann, Suresh B. Lakshminarayana, Shi Hua Ang, Seh Yong Leong, Jocelyn Tan, Josephine Wong, Sonja Keller-Maerki, Christoph Fischli, Anne Goh, Esther K. Schmitt, Philipp Krastel, Eric Francotte, Kelli Kuhen, David Plouffe, Kerstin Henson, Trixie Wagner, Elizabeth A. Winzeler, Frank Petersen, Reto Brun, Veronique Dartois, Thierry T. Diagana, Thomas H. Keller (2010). "Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria". Journal of Medicinal Chemistry. 53 (14): 5155–5164. doi:10.1021/jm100410f. ISSN 0022-2623. Cite uses deprecated parameter |coauthors= (help)
  2. ↑ Rottmann, M.; C. McNamara, B. K. S. Yeung, M. C. S. Lee, B. Zou, B. Russell, P. Seitz, D. M. Plouffe, N. V. Dharia, J. Tan, S. B. Cohen, K. R. Spencer, G. E. Gonzalez-Paez, S. B. Lakshminarayana, A. Goh, R. Suwanarusk, T. Jegla, E. K. Schmitt, H.-P. Beck, R. Brun, F. Nosten, L. Renia, V. Dartois, T. H. Keller, D. A. Fidock, E. A. Winzeler, T. T. Diagana (2010). "Spiroindolones, a Potent Compound Class for the Treatment of Malaria". Science. 329 (5996): 1175–1180. doi:10.1126/science.1193225. ISSN 0036-8075. PMC 3050001Freely accessible. PMID 20813948. Cite uses deprecated parameter |coauthors= (help)


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