Subependymoma

Subependymoma
Micrograph of a subependymoma showing the characteristic clustering of nuclei. H&E stain.
Classification and external resources
ICD-O 9383/1
DiseasesDB 34807
Subependymomas of the fourth ventricle, extending into the cerebellopontine angle via the foramen of Luschka, right side of illustration.

A subependymoma is a type of brain tumor; specifically, it is a rare form of ependymal tumor.[1]

The prognosis for a subependymoma is better than for most ependymal tumors,[2] and is considered a grade I/IV tumor in the World Health Organization (WHO) classification.

They are classically found within the fourth ventricle, typically have a well demarcated interface to normal tissue and do not usually extend into the brain parenchyma, like ependymomas often do.[3]

Diagnosis

The diagnosis is based on tissue, e.g. a biopsy. Histologically subependymomas consistent of microcystic spaces and bland appearing cells without appreciable nuclear atypia or mitoses. The nuclei tend to form clusters.

References

  1. Orakcioglu B, Schramm P, Kohlhof P, Aschoff A, Unterberg A, Halatsch ME (January 2009). "Characteristics of thoracolumbar intramedullary subependymomas". J Neurosurg Spine. 10 (1): 54–9. doi:10.3171/2008.10.SPI08311. PMID 19119934.
  2. Prayson RA, Suh JH (April 1999). "Subependymomas: clinicopathologic study of 14 tumors, including comparative MIB-1 immunohistochemical analysis with other ependymal neoplasms". Arch. Pathol. Lab. Med. 123 (4): 306–9. doi:10.1043/0003-9985(1999)123<0306:S>2.0.CO;2. PMID 10320142.
  3. Hoeffel, C.; Boukobza, M.; Polivka, M.; Lot, G.; Guichard, JP.; Lafitte, F.; Reizine, D.; Merland, JJ. (1995). "MR manifestations of subependymomas.". AJNR Am J Neuroradiol. 16 (10): 2121–9. PMID 8585504.
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