TRAF3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW

Identifiers

Aliases

TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3

External IDs

MGI: 108041 HomoloGene: 7981 GeneCards: TRAF3

Genetically Related Diseases

schizophrenia^[1]

Gene ontology
Molecular function	• zinc ion binding • signal transducer activity • metal ion binding • ligase activity • protein binding • thioesterase binding • tumor necrosis factor receptor binding • protein phosphatase binding • protein kinase binding • ubiquitin protein ligase binding • ubiquitin-protein transferase activity
Cellular component	• cytoplasm • cytosol • endosome • mitochondrion • cytoplasmic side of plasma membrane • CD40 receptor complex
Biological process	• regulation of apoptotic process • Toll signaling pathway • immune system process • TRIF-dependent toll-like receptor signaling pathway • protein ubiquitination • negative regulation of type I interferon production • negative regulation of NF-kappaB transcription factor activity • regulation of proteolysis • apoptotic process • toll-like receptor signaling pathway • regulation of cytokine production • signal transduction • regulation of interferon-beta production • innate immune response • tumor necrosis factor-mediated signaling pathway • regulation of defense response to virus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7187


22031

Ensembl


ENSG00000131323


ENSMUSG00000021277

UniProt


Q13114


Q60803

RefSeq (mRNA)


NM_001199427 NM_003300 NM_145725 NM_145726


NM_001048206 NM_001286122 NM_011632

RefSeq (protein)


NP_001186356.1 NP_003291.2 NP_663777.1 NP_663778.1


NP_035762.2

Location (UCSC)

Chr 14: 102.78 – 102.91 Mb

Chr 12: 111.17 – 111.27 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

TNF receptor-associated factor is a protein that in humans is encoded by the TRAF3 gene. ^[4]^[5]^[6]

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[7]

Interactions

TRAF3 has been shown to interact with:

CD27,^[8]^[9]
CD40,^[10]^[11]^[12]^[13]
Caspase 3^[14]^[15]
Lymphotoxin beta receptor,^[16]^[17]^[18]
Nucleoporin 62,^[19]
RANK,^[20]^[21]
TANK,^[22]^[23] and
TNFSF14.^[24]

References

↑ "Diseases that are genetically associated with TRAF3 view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D (March 1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science. 267 (5203): 1494–8. doi:10.1126/science.7533327. PMID 7533327.
↑ Sato T, Irie S, Reed JC (January 1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40". FEBS Letters. 358 (2): 113–8. doi:10.1016/0014-5793(94)01406-Q. PMID 7530216.
↑ Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (February 1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family". Cell. 80 (3): 389–99. doi:10.1016/0092-8674(95)90489-1. PMID 7859281.
↑ "Entrez Gene: TRAF3 TNF receptor-associated factor 3".
↑ Yamamoto H, Kishimoto T, Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". Journal of Immunology. 161 (9): 4753–9. PMID 9794406.
↑ Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry. 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMID 9582383.
↑ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446. PMID 9990007.
↑ Hu HM, O'Rourke K, Boguski MS, Dixit VM (December 1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". The Journal of Biological Chemistry. 269 (48): 30069–72. PMID 7527023.
↑ Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR (September 2000). "Molecular basis for CD40 signaling mediated by TRAF3". Proceedings of the National Academy of Sciences of the United States of America. 97 (19): 10395–9. doi:10.1073/pnas.97.19.10395. PMC 27035. PMID 10984535.
↑ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (December 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". The EMBO Journal. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
↑ Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH (March 2001). "Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells". Journal of Leukocyte Biology. 69 (3): 490–6. PMID 11261798.
↑ Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC (March 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". The Journal of Biological Chemistry. 276 (11): 8087–93. doi:10.1074/jbc.M009450200. PMID 11098060.
↑ VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217.
↑ Wu MY, Wang PY, Han SH, Hsieh SL (April 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells". The Journal of Biological Chemistry. 274 (17): 11868–73. doi:10.1074/jbc.274.17.11868. PMID 10207006.
↑ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
↑ Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S. "TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes". Molecular Immunology. 37 (1-2): 73–84. doi:10.1016/s0161-5890(00)00015-8. PMID 10781837.
↑ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (December 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". The Journal of Biological Chemistry. 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. PMID 9852070.
↑ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Letters. 443 (3): 297–302. doi:10.1016/s0014-5793(98)01731-1. PMID 10025951.
↑ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
↑ Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
↑ Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological Chemistry. 278 (16): 14363–9. doi:10.1074/jbc.M208672200. PMID 12571250.

Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular Signalling. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
Bradley JR, Pober JS (October 2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Saha SK, Cheng G (April 2006). "TRAF3: a new regulator of type I interferons". Cell Cycle. 5 (8): 804–7. doi:10.4161/cc.5.8.2637. PMID 16582590.
Hu HM, O'Rourke K, Boguski MS, Dixit VM (December 1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". The Journal of Biological Chemistry. 269 (48): 30069–72. PMID 7527023.
Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D (March 1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science. 267 (5203): 1494–8. doi:10.1126/science.7533327. PMID 7533327.
Hsu H, Shu HB, Pan MG, Goeddel DV (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell. 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. PMID 8565075.
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity. 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. PMID 8612133.
Butch ER, Guan KL (February 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". The Journal of Biological Chemistry. 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. PMID 8626767.
Gedrich RW, Gilfillan MC, Duckett CS, Van Dongen JL, Thompson CB (May 1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins". The Journal of Biological Chemistry. 271 (22): 12852–8. doi:10.1074/jbc.271.22.12852. PMID 8662842.
Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K (June 1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". The Journal of Biological Chemistry. 271 (25): 14661–4. doi:10.1074/jbc.271.25.14661. PMID 8663299.
Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (June 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217.
Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
Boucher LM, Marengère LE, Lu Y, Thukral S, Mak TW (April 1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochemical and Biophysical Research Communications. 233 (3): 592–600. doi:10.1006/bbrc.1997.6509. PMID 9168896.
Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M (September 1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proceedings of the National Academy of Sciences of the United States of America. 94 (18): 9792–6. doi:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204.
Force WR, Cheung TC, Ware CF (December 1997). "Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor". The Journal of Biological Chemistry. 272 (49): 30835–40. doi:10.1074/jbc.272.49.30835. PMID 9388227.

PDB gallery

1flk: MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3

1fll: MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3

1kzz: DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3

1l0a: DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3

1rf3: Structurally Distinct Recognition Motifs in Lymphotoxin-B Receptor and CD40 for TRAF-mediated Signaling

1zms: LMP1 Protein binds to TRAF3 as a structural CD40

2gkw: Key contacts promote recognition of BAFF-R by TRAF3

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT

see JAK-STAT signaling pathway

Growth factor receptor-bound protein

Other

14-3-3 YWHAE YWHAZ Caveolin Cortactin Death-inducing signaling complex Paxillin MYD88 SMAD TRAF TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6) BIN1 SH3BP2 LDB3

CHM CHML

Cytokine receptor modulators

Chemokine

See here instead.

CSF

Erythropoietin	Agonists: ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)

G-CSF (CSF3)	Agonists: Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim

GM-CSF (CSF2)	Agonists: Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies: Mavrilimumab MOR103 Namilumab

M-CSF (CSF1)	Agonists: Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors: Agerafenib

SCF (c-Kit)	See here instead.

Thrombopoietin	Agonists: Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1, IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies: Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors: Bifarcept

IFNGR (γ, II)	Agonists: Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies: Emapalumab Fontolizumab

IFNLR (λ, III)	See IL-28R (IFNLR) here instead.

Interleukin

See here instead.

TGFβ

See here instead.

TNF

See here instead.

Others

JAK
(inhibitors)

JAK1	Baricitinib Filgotinib Momelotinib Ruxolitinib Tofacitinib (tasocitinib, CP-690550) Upadacitinib

JAK2	AG-490 Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Lestaurtinib NSC-7908 NSC-33994 Pacritinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib, CP-690550)

JAK3	AG-490 Cercosporamide TCS-21311 Tofacitinib (tasocitinib, CP-690550) WHI-P 154 ZM-39923 ZM-449829

Others

Additional cytokines: Cardiotrophin 1 (CT-1)
FMS-like tyrosine kinase 3 ligand (FLT3L)
Leukemia/leukocyte inhibitory factor (LIF)
Oncostatin M (OSM)
Thymic stromal lymphopoietin (TSLP)

Additional cytokine receptor modulators: Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

See also: Peptide receptor modulators
Growth factor receptor modulators

This article is issued from Wikipedia - version of the 5/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

TRAF3

Function

Interactions

References

Further reading